Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-Y-PLXNA2 [plasma membrane]
Stable Identifier
R-HSA-419607
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
phosphorylated Plexin-A2
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
CRMPs in Sema3A signaling (Homo sapiens)
Tyrosine phosphorylation of CRMPs by Fes (Homo sapiens)
Sema3A:NP-1:Plexin-A:Fes:CRMP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA2 [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA2 [plasma membrane] (Homo sapiens)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)
Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA2 [plasma membrane] (Homo sapiens)
Phosphorylation of Plexin-A (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA2 [plasma membrane] (Homo sapiens)
Rac1 binds PlexinA (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA2 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA2 [plasma membrane] (Homo sapiens)
Recruitment of Rnd1 to Plexin A (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA2 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA2 [plasma membrane] (Homo sapiens)
Sema3A PAK dependent Axon repulsion (Homo sapiens)
Activation of PAK by Rac1 (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA2 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA2 [plasma membrane] (Homo sapiens)
Autophosphorylation of PAK (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA2 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA2 [plasma membrane] (Homo sapiens)
Phosphorylation of LIMK-1 by PAK (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75051 PLXNA2
Gene Names
PLXNA2, KIAA0463, OCT, PLXN2, UNQ209/PRO235
Chain
signal peptide:1-34, chain:35-1894
Reference Genes
BioGPS Gene:5362 PLXNA2
COSMIC (genes):PLXNA2 PLXNA2
CTD Gene:5362 PLXNA2
dbSNP Gene:5362 PLXNA2
ENSEMBL:ENSG00000076356 PLXNA2
ENSEMBL_homo_sapiens_GENE:ENSG00000076356.7 PLXNA2
HGNC:9100 PLXNA2
KEGG Gene (Homo sapiens):5362 PLXNA2
Monarch:5362 PLXNA2
NCBI Gene:5362 PLXNA2
OMIM:601054 PLXNA2
UCSC:O75051 PLXNA2
Reference Transcript
RefSeq:NM_025179.3 PLXNA2
Other Identifiers
11720562_a_at
11720563_at
16698816
207290_PM_at
207290_at
213030_PM_s_at
213030_s_at
227032_PM_at
227032_at
2453366
2453367
2453369
2453371
2453372
2453373
2453374
2453378
2453382
2453384
2453387
2453388
2453389
2453390
2453392
2453393
2453396
2453398
2453399
2453401
2453402
2453403
2453404
2453406
2453413
2453414
2453415
2453419
2453421
2453422
2453424
2453425
2453440
2453457
2453459
2453460
2453464
40395_at
5362
54877_at
7923991
A_23_P307544
A_23_P46618
GE476341
GE53202
GO:0001756
GO:0002116
GO:0005515
GO:0005886
GO:0007155
GO:0007162
GO:0007166
GO:0008360
GO:0016020
GO:0017154
GO:0021915
GO:0021935
GO:0023052
GO:0030154
GO:0030334
GO:0042802
GO:0048856
GO:0048870
GO:0050772
GO:0051642
GO:0060037
GO:0060089
GO:0060174
GO:0071526
GO:1902287
HMNXSV003002733
HMNXSV003022410
Hs.290927.0.A1_3p_at
Hs.300622.1.S1_3p_a_at
ILMN_1680617
ILMN_1844408
PH_hs_0015467
PH_hs_0032777
TC01003778.hg
TC01006075.hg
g13378152_3p_at
Participates
as a member of
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
Other forms of this molecule
PLXNA2 [plasma membrane]
Inferred To
phospho-PlexA [plasma membrane]
(Drosophila melanogaster)
phospho-Plxna2 [plasma membrane]
(Mus musculus)
phospho-Plxna2 [plasma membrane]
(Rattus norvegicus)
phospho-plx-1 [plasma membrane]
(Caenorhabditis elegans)
phospho-plxna2 [plasma membrane]
(Xenopus tropicalis)
phospho-PLXNA2 [plasma membrane]
(Bos taurus)
phospho-PLXNA2 [plasma membrane]
(Sus scrofa)
phospho-p-Y-PLXNA2 [plasma membrane]
(Danio rerio)
phospho-p-Y-PLXNA2 [plasma membrane]
(Gallus gallus)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_079455.3
OpenTargets
ENSG00000076356
GeneCards
O75051
HPA
ENSG00000076356-PLXNA2
Ensembl
ENSP00000356000
,
ENSG00000076356
,
ENST00000367033
PRO
O75051
Pharos - Targets
O75051
Orphanet
24816
PDB
3Q3J
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P39688 Fyn
6
Fyn [cytosol]
(R-MMU-420333)
MyrG,p-Y420-Fyn [plasma membrane]
(R-MMU-9037733)
phospho-p-Y420-FYN [cytosol]
(R-MMU-391821)
pFyn(Y531) [cytosol]
(R-MMU-420350)
pFyn (420) [cytosol]
(R-MMU-420335)
phospho-p-S21,Y420-FYN [cytosol]
(R-MMU-5218745)
0.499
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text