Reactome | Calcitonin-like ligand receptors

Calcitonin-like ligand receptors

Stable Identifier

R-HSA-419812

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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The calcitonin peptide family comprises calcitonin, amylin, calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and intermedin (AM2). Calcitonin is a 32 amino acid peptide, involved in bone homeostasis (Sexton PM et al, 1999). Amylin is a product of the islet beta-cell (Cooper GJ et al, 1987), along with insulin and probably has a hormonal role in the regulation of nutrient intake (Young A and Denaro M, 1998). Adrenomedullin (AM) is a ubiquitously expressed peptide initially isolated from phaechromocytoma (a tumour of the adrenal medulla) (Kitamura K et al, 1993). Both AM and AM2 (Takei Y et al, 2004) belong to a family of calcitonin-related peptide hormones important for regulating diverse physiologic functions and the chemical composition of fluids and tissues.
The receptor family for these peptides consists of two class B GPCRs, the calcitonin receptor (CT) and calcitonin receptor-like receptor (CL) (Poyner DR er al, 2002). Whilst the receptor for calcitonin is a conventional class B GPCR, the receptors for CGRP, AM and amylin require additional proteins, called the receptor activity modifying proteins (RAMPs). There are three RAMPs in mammals; they interact with the CT receptor to convert it to receptors for amylin. For CGRP and AM, the related CL interacts with RAMP1 to give a CGRP receptor and RAMP2 or 3 to give AM receptors. CL by itself will bind no known endogenous ligand.

Literature References

PubMed ID	Title	Journal	Year
10519914	Calcitonin Sexton, PM, Findlay, DM, Martin, TJ	Curr Med Chem	1999
9646295	Roles of amylin in diabetes and in regulation of nutrient load Young, A, Denaro, M	Nutrition	1998
8387282	Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma Kitamura, K, Kangawa, K, Kawamoto, M, Ichiki, Y, Nakamura, S, Matsuo, H, Eto, T	Biochem Biophys Res Commun	1993
14706825	Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator Takei, Y, Inoue, K, Ogoshi, M, Kawahara, T, Bannai, H, Miyano, S	FEBS Lett	2004
12037140	International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors Poyner, DR, Sexton, PM, Marshall, I, Smith, DM, Quirion, R, Born, W, Muff, R, Fischer, JA, Foord, SM	Pharmacol Rev	2002
3317417	Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients Cooper, GJ, Willis, AC, Clark, A, Turner, RC, Sim, RB, Reid, KB	Proc Natl Acad Sci U S A	1987