Reactome | SCT [extracellular region]

SCT [extracellular region]

Stable Identifier

R-HSA-420060

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Secretin, SECR_HUMAN

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Leishmania parasite growth and survival (Homo sapiens)
      - Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        SCTR:SCT [plasma membrane] (Homo sapiens)
        
        SCT [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P09683 SCT

Gene Names

SCT

Chain

signal peptide:1-18, propeptide:19-26, peptide:28-54, propeptide:58-121

Reference Genes

BioGPS Gene:6343 SCT

COSMIC (genes):SCT SCT

CTD Gene:6343 SCT

dbSNP Gene:6343 SCT

ENSEMBL:ENSG00000070031 SCT

ENSEMBL:ENSG00000274473 SCT

HGNC:10607 SCT

KEGG Gene (Homo sapiens):6343 SCT

Monarch:6343 SCT

NCBI Gene:6343 SCT

OMIM:182099 SCT

UCSC:P09683 SCT

Reference Transcript

RefSeq:NM_021920.3 SCT

Other Identifiers

0004570170

11742661_at

16734040

221198_at

3358240

3358242

3358243

3358244

3358245

3358246

3358247

50961

6343

7945498

A_23_P104594

AAG31443

AF244355

CCDS7709

ENSG00000070031

ENSG00000274473

ENSP00000176195

ENSP00000483559

ENST00000176195

ENST00000176195.3

ENST00000622382

EntrezGene:6343

EntrezGene:SCT

g12545379_3p_at

GO:0001664

GO:0002024

GO:0003674

GO:0005102

GO:0005179

GO:0005575

GO:0005576

GO:0005615

GO:0005623

GO:0006629

GO:0006810

GO:0007165

GO:0007186

GO:0007267

GO:0007420

GO:0008150

GO:0009056

GO:0009790

GO:0009992

GO:0021766

GO:0030157

GO:0031667

GO:0032098

GO:0042592

GO:0043950

GO:0046659

GO:0047485

GO:0048167

GO:0048566

GO:0048856

GO:0050996

GO:0090187

GO:0090274

GO:1903640

HGNC:10607

HPA050961

ILMN_1705763

IPR000532

IPR015675

MIM:182099

NM_021920

NP_068739

PF00123

PH_hs_0029684

SCT

SCT-201

SCT-202

SM00070

TC11001243.hg

UPI00001357C7

Participant Of

input

Secretin receptor binds secretin

hasMember

Ligands of GPCRs that activate Gs [extracellular region]

hasComponent

SCTR:SCT [plasma membrane]

Inferred To

SCT [extracellular region] (Bos taurus)

SCT [extracellular region] (Sus scrofa)

Sct [extracellular region] (Mus musculus)

Sct [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_068739.1

OpenTargets

ENSG00000070031

HPA

ENSG00000070031-SCT

GeneCards

P09683

Ensembl

ENSG00000274473, ENST00000176195, ENSP00000176195, ENST00000622382, ENSP00000483559, ENSG00000070031

PRO

P09683

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:O14770-4 MEIS2			0.556	3
UniProt:O14964 HGS	2	HGS [phagocytic vesicle lumen] (R-HSA-9635660) HGS [cytosol] (R-HSA-182954)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3

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