Reactome | IAPP(34-70) [extracellular region]

IAPP(34-70) [extracellular region]

Stable Identifier

R-HSA-420076

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Amylin, Islet amyloid polypeptide, IAPP, IAPP_HUMAN

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Amyloid fiber formation (Homo sapiens)
  - Amyloid fibrils have additional components (Homo sapiens)
    - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
      - Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Islet amyloid polypeptide fibril [extracellular region] (Homo sapiens)
        
        IAPP(34-70) [extracellular region] (Homo sapiens)
    - Amyloid fibrils [plasma membrane] (Homo sapiens)
      - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Islet amyloid polypeptide fibril [extracellular region] (Homo sapiens)
        
        IAPP(34-70) [extracellular region] (Homo sapiens)
  - Amyloid precursor proteins form ordered fibrils (Homo sapiens)
    - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
      - Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Islet amyloid polypeptide fibril [extracellular region] (Homo sapiens)
        
        IAPP(34-70) [extracellular region] (Homo sapiens)
    - Amyloid fibril monomers [extracellular region] (Homo sapiens)
      - Localized amyloid fibril monomers [extracellular region] (Homo sapiens)
        
        IAPP(34-70) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P10997 IAPP

Gene Names

IAPP

Chain

signal peptide:1-22, propeptide:23-31, peptide:34-70, propeptide:74-89

Reference Genes

BioGPS Gene:3375 IAPP

COSMIC (genes):IAPP IAPP

CTD Gene:3375 IAPP

dbSNP Gene:3375 IAPP

ENSEMBL:ENSG00000121351 IAPP

HGNC:5329 IAPP

KEGG:hsa:3375 IAPP

Monarch:3375 IAPP

NCBI Gene:3375 IAPP

OMIM:147940 IAPP

UCSC:P10997 IAPP

Reference Transcript

Other Identifiers

11723219_s_at

11723220_at

16749095

207062_PM_at

207062_at

3375

3407771

3407774

3407775

3407776

3407777

3407778

3407779

37871_at

7954377

A_14_P114224

A_14_P200342

A_23_P139648

GE492397

GO:0001540

GO:0005102

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0006915

GO:0007165

GO:0007267

GO:0008289

GO:0010739

GO:0012501

GO:0019233

GO:0023052

GO:0030154

GO:0030316

GO:0031333

GO:0042755

GO:0042802

GO:0043065

GO:0043410

GO:0045453

GO:0045671

GO:0045779

GO:0048018

GO:0050850

GO:0050877

GO:0097647

GO:0098772

GO:1905907

HMNXSV003026176

ILMN_1679527

PH_hs_0008384

TC12000230.hg

g4557654_3p_at

Participates

as a member of

as a repeated unit of

Islet amyloid polypeptide fibril [extracellular region] (Homo sapiens)

as an input of

AMY1-3 bind IAPP(34-70) (Homo sapiens)

as a component of

AMY1-3:IAPP(34-70) [plasma membrane] (Homo sapiens)

Other forms of this molecule

IAPP(1-89) [cytosol]

Inferred To

IAPP [extracellular region] (Bos taurus)

IAPP [extracellular region] (Canis familiaris)

IAPP(34-70) [extracellular region] (Gallus gallus)

Iapp [extracellular region] (Mus musculus)

Iapp [extracellular region] (Rattus norvegicus)

iapp [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_001316130.1, NP_000406.1

OpenTargets

ENSG00000121351

ENSEMBL

ENSP00000240652, ENST00000240652, ENSG00000121351, ENST00000539393, ENSP00000437357

HPA

ENSG00000121351-IAPP

GeneCards

IAPP

ZINC - Substances

IAPP_HUMAN

ZINC target

P10997

PRO

P10997

Pharos - Targets

P10997

PDB

8AZ2, 8AZ4, 8F2A, 5KNZ, 3FTH, 8R4I, 7M64, 3FPO, 3G7W, 7BG0, 3DG1, 6UCJ, 8AZ7, 8AZ6, 7YL7, 7YL3, 3FR1, 5MGQ, 3HGZ, 1KUW, 6ZRR, 3FTL, 3FTR, 2KB8, 8AZ1, 8AZ3, 5K5G, 8F2B, 7M65, 6VW2, 7M61, 8YG2, 5KO0, 7YL0, 6UCK, 8AZ5, 7YKW, 3G7V, 2G48, 6ZRF, 6ZRQ, 2L86, 7M62, 8AWT, 3FTK, 8AZ0, 8F0K, 8F0J, 6Y1A

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10997 IAPP	2	IAPP(34-70) [extracellular region] (R-HSA-420076) IAPP(1-89) [cytosol] (R-HSA-186631)	0.952	14
UniProt:P14735-1 IDE			0.618	3
UniProt:P56817 BACE1	8	BACE1 [endosome membrane] (R-HSA-5692942) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) 7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326)	0.558	2
UniProt:Q9Y5Z0 BACE2			0.558	3