Glucagon-like receptor 2 binds GLP2

Stable Identifier
R-HSA-420123
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Glucagon-like peptide 2 (GLP-2) (Drucker DJ 1999) is a 33-aa proglucagon-derived peptide produced by intestinal enteroendocrine cells. GLP-2 stimulates intestinal growth. The effects of GLP-2 are mediated by the GLP2 receptor (Munroe DG et al, 1999), which can couple with G protein alpha s subunit that activates adenylyl cyclase (Koehler JA et al, 2005).

Literature References
PubMed ID Title Journal Year
15471943 The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways

Koehler, JA, Yusta, B, Drucker, DJ

Mol Endocrinol 2005
9990065 Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2

Munroe, DG, Gupta, AK, Kooshesh, F, Vyas, TB, Rizkalla, G, Wang, H, Demchyshyn, L, Yang, ZJ, Kamboj, RK, Chen, H, McCallum, K, Sumner-Smith, M, Drucker, DJ, Crivici, A

Proc Natl Acad Sci U S A 1999
10322410 Glucagon-like Peptide 2

Drucker, DJ

Trends Endocrinol Metab 1999
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