Secretin receptor binds secretin

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Secretin (SCT) (Whitmore TE et al, 2000) is a peptide hormone belonging to the glucagon peptide hormone family and is produced in the duodenum. Its primary effect is to regulate the pH of the duodenal contents via the control of gastric acid secretion and buffering with bicarbonate. These effects are mediated by the SCT receptor (Patel DR et al, 1995). The receptor activity is mediated by coupling to G protein alpha s subunits, which stimulate adenylyl cyclase which increases intracellular cAMP levels (Patel DR et al, 1995).

Literature References
PubMed ID Title Journal Year
11060443 Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA

Whitmore, TE, Quinton, TJ, Scherer, SW, Lok, S, Vincent, JB, Maurer, MF, Lofton-Day, CE, Holloway, JL, Chen, L

Cytogenet Cell Genet 2000
7700244 Molecular cloning and expression of a human secretin receptor

Sreedharan, SP, Kong, Y, Patel, DR

Mol Pharmacol 1995
Orthologous Events
Cite Us!