The adrenomedullin receptor can bind adrenomedullin and intermedin

Stable Identifier
R-HSA-420214
Type
Reaction
Species
Homo sapiens
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Summation

Intermedin (AM2) (Roh J et al, 2004) and adrenomedullin (AM) (Kitamura K et al, 1993) belong to the calcitonin peptide hormone family and are important for cardiovascular and respiratory regulation. The functional adrenomedullin receptor AM1 is composed of the calcitonin gene-related peptide receptor (CGPR) and receptor activity modifying protein 2 (RAMP2) (Kamitani S et al, 1999). AM1 receptor can bind either of these peptide hormones and its activity is mediated by coupling with the G protein alpha s subunit which stimulates adenylyl cyclase and increases intracellular cAMP levels (Aiyar N et al, 2001). The function of the AM2 receptor (formed by the combination of CGPR and RAMP3) is very similar to that of AM1.

Literature References
PubMed ID Title Journal Year
10217420 The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells

Kamitani, S, Asakawa, M, Shimekake, Y, Kuwasako, K, Nakahara, K, Sakata, T

FEBS Lett 1999
9620797 RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

McLatchie, LM, Fraser, NJ, Main, MJ, Wise, A, Brown, J, Thompson, N, Solari, R, Lee, MG, Foord, SM

Nature 1998
14615490 Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes

Roh, J, Chang, CL, Bhalla, A, Klein, C, Hsu, SY

J Biol Chem 2004
11693189 Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells

Aiyar, N, Disa, J, Pullen, M, Nambi, P

Mol Cell Biochem 2001
8387282 Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma

Kitamura, K, Kangawa, K, Kawamoto, M, Ichiki, Y, Nakamura, S, Matsuo, H, Eto, T

Biochem Biophys Res Commun 1993
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