Reactome: A Curated Pathway Database

The adrenomedullin receptor can bind adrenomedullin and intermedin

Stable Identifier
R-HSA-420214
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Intermedin (AM2) (Roh J et al, 2004) and adrenomedullin (AM) (Kitamura K et al, 1993) belong to the calcitonin peptide hormone family and are important for cardiovascular and respiratory regulation. The functional adrenomedullin receptor AM1 is composed of the calcitonin gene-related peptide receptor (CGPR) and receptor activity modifying protein 2 (RAMP2) (Kamitani S et al, 1999). AM1 receptor can bind either of these peptide hormones and its activity is mediated by coupling with the G protein alpha s subunit which stimulates adenylyl cyclase and increases intracellular cAMP levels (Aiyar N et al, 2001). The function of the AM2 receptor (formed by the combination of CGPR and RAMP3) is very similar to that of AM1.

Literature References
Participants
Participant Of
Orthologous Events