VIP receptors bind VIP

Stable Identifier
R-HSA-420233
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Vasoactive intestinal peptide (VIP) (Tsukada T et al, 1985) belongs to the glucagon hormone family and is expressed in many parts of the human body. VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial muscle contraction and increases glycogenolysis. It also relaxes the smooth muscle of trachea, stomach and gall bladder. The effects of VIP are mediated by the VIP receptors of which there are two, 1 and 2 (Sreedharan SP et al, 1993 and Svodoba M et al, 1994 respectively). The actions of the receptor are mediated by coupling with the G protein alpha s subunit, which stimulates adenylyl cyclase which increases intracellular cAMP levels (Sreedharan SP et al, 1993).

Literature References
PubMed ID Title Journal Year
7811244 Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts

Svoboda, M, Tastenoy, M, Van Rampelbergh, J, Goossens, JF, De Neef, P, Waelbroeck, M, Robberecht, P

Biochem Biophys Res Commun 1994
3899557 Structure of the human vasoactive intestinal polypeptide gene

Tsukada, T, Horovitch, SJ, Montminy, MR, Mandel, G, Goodman, RH

DNA 1985
8390245 Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor

Sreedharan, SP, Patel, DR, Huang, JX, Goetzl, EJ

Biochem Biophys Res Commun 1993
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