Reactome | GHRH receptor binds GHRH

GHRH receptor binds GHRH

Stable Identifier

R-HSA-420243

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Growth hormone-releasing hormone (GHRH, somatocrinin, growth hormone-releasing factor) (Gubler U et al, 1983) is released from neurosecretory cells in the hypothalamus and along with the inhibitory peptide, somatostatin, mediates the neuroendocrine regulation of pituitary growth hormone synthesis and secretion. The GHRH receptor (Gaylinn BD et al, 1993) is expressed in the pituitary gland and mediates the activity of GHRH. Downstream signalling is mediated by coupling to the G protein alpha s subunit, which stimulates adenylyl cyclase which increases intracellular cAMP levels (Mayo KE, 1992).

Literature References

PubMed ID	Title	Journal	Year
7680413	Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone Zysk, JR, Thorner, MO, Lyons, CE, Lynch, KR, Gaylinn, BD, Harrison, JK	Mol Endocrinol	1993
1333056	Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone Mayo, KE	Mol Endocrinol	1992
6192430	Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin Collier, KJ, Zeytin, F, Esch, F, Poonian, MS, Monahan, JJ, Bhatt, RS, Hoffman, BJ, Ling, N, Gage, LP, Gubler, U, Brazeau, P, Bohlen, P, Lomedico, PT	Proc Natl Acad Sci U S A	1983