Reactome: A Curated Pathway Database

Amylin receptors can bind Amylin

Stable Identifier
R-HSA-420265
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Amylin (islet amyloid polypeptide, diabetes associated peptide) is a 37 amino acid peptide first purified from amyloid deposits in the pancreatic islets of type 2 diabetic patients (Nishi M et al, 1989). It is a product of the islet B-cell, along with insulin and probably has a hormonal role in the regulation of nutrient intake. Amylin receptors are multimeric complexes, formed by CT receptor (Gorn AH et al, 1992) interaction with receptor activity modifying proteins (RAMPs) (McLatchie LM et al, 1998). The CT receptor interacts with the three RAMPs, generating multiple subtypes of amylin receptor (AMY1-3).

Literature References
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Orthologous Events