GIP receptor binds gastric inhibitory peptide

Stable Identifier
R-HSA-420274
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Gastric inhibitory polypeptide (GIP, glucose-dependent insulinotropic peptide) (Moody AJ et al, 1984) is a member of the secretin family of hormones. It is synthesized and secreted from endocrine cells in the small intestine. GIP induces insulin secretion, which is primarily stimulated by hyperosmolarity of glucose in the duodenum. Gastric inhibitory polypeptide receptors are found on beta-cells in the pancreas (Volz A et al, 1995). Their effects are mediated by coupling to the G protein alpha s subunit, which stimulates adenylyl cyclase which can increase intracellular cAMP levels (Bollag RJ et al, 2000).
Literature References
PubMed ID Title Journal Year
10698200 Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors

Isales, CM, Qin, F, Rasmussen, H, Zhong, Q, Bollag, RJ, Zhong, L, Min, L, Phillips, P, Mulloy, AL, Ding, KH, Cameron, R

Endocrinology 2000
6745415 The isolation and sequencing of human gastric inhibitory peptide (GIP)

Valverde, I, Thim, L, Moody, AJ

FEBS Lett 1984
7589426 Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma

Göke, R, Fehmann, HC, Göke, B, Bode, HP, Volz, A, Lankat-Buttgereit, B

FEBS Lett 1995
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!