Reactome | PTH1R [plasma membrane]

PTH1R [plasma membrane]

Stable Identifier

R-HSA-420479

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Parathyroid hormone/parathyroid hormone-related peptide receptor, PTH1R_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class B/2 (Secretin family receptors) (Homo sapiens)
      - Parathyroid hormone receptor can bind parathyroid hormone (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
        
        PTH1R,PTH2R [plasma membrane] (Homo sapiens)
        
        PTH1R [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q03431 PTH1R

Gene Names

PTH1R, PTHR, PTHR1

Chain

signal peptide:1-26, chain:27-593

Reference Genes

BioGPS Gene:5745 PTH1R

COSMIC (genes):PTH1R PTH1R

CTD Gene:5745 PTH1R

dbSNP Gene:5745 PTH1R

ENSEMBL:ENSG00000160801 PTH1R

ENSEMBL:ENSG00000160801.14 PTH1R

HGNC:9608 PTH1R

KEGG Gene (Homo sapiens):5745 PTH1R

Monarch:5745 PTH1R

NCBI Gene:5745 PTH1R

OMIM:168468 PTH1R

UCSC:Q03431 PTH1R

Reference Transcript

Other Identifiers

11725200_a_at

16940239

205911_PM_at

205911_at

2621033

2621034

2621037

2621038

2621039

2621047

2621052

2621053

2621054

2621055

2621058

2621060

2621061

2621063

2621064

2621065

2621067

2621070

2621073

2621075

2621078

2621079

532_at

533_g_at

5745

8079433

A_23_P167030

GE58971

GO:0001501

GO:0001503

GO:0001701

GO:0002062

GO:0002076

GO:0004888

GO:0004930

GO:0004991

GO:0005515

GO:0005634

GO:0005737

GO:0005886

GO:0005975

GO:0006874

GO:0007165

GO:0007166

GO:0007186

GO:0007187

GO:0007188

GO:0007189

GO:0007200

GO:0008283

GO:0008284

GO:0008285

GO:0016020

GO:0016323

GO:0016324

GO:0017046

GO:0023052

GO:0030154

GO:0030282

GO:0042803

GO:0043226

GO:0043235

GO:0043621

GO:0045453

GO:0048469

GO:0048856

GO:0055065

GO:0060089

GO:0060732

HMNXSV003000208

ILMN_1795166

PH_hs_0000130

PH_hs_0030862

TC03000262.hg

U17418_at

g4506270_3p_at

Participates

as a member of

PTH1R,PTH2R [plasma membrane] (Homo sapiens)

Inferred To

Homologues of PTH1R [plasma membrane] (Sus scrofa)

pth1ra [plasma membrane] (Danio rerio)

Pth1r [plasma membrane] (Mus musculus)

Pth1r [plasma membrane] (Rattus norvegicus)

pth1r [plasma membrane] (Xenopus tropicalis)

PTH1R [plasma membrane] (Bos taurus)

PTH1R [plasma membrane] (Canis familiaris)

PTH1R [plasma membrane] (Gallus gallus)

PTH1R [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_000307.1, NP_001171673.1, XP_016862422.1

Guide to Pharmacology - Targets

331

OpenTargets

ENSG00000160801

ZINC - Substances

PTH1R_HUMAN

ZINC target

Q03431

PRO

Q03431

PDB

7VVK, 7UZP, 7VVL, 6NBF, 7VVM, 7VVO, 3H3G, 5EMB, 7VVJ, 3L2J, 6NBH, 1BL1, 3C4M, 7VVN, 8HAO, 4Z8J, 8HA0, 6NBI, 8HAF

HPA

ENSG00000160801-PTH1R

GeneCards

Q03431

Ensembl

ENST00000418619, ENSP00000413774, ENSP00000321999, ENSG00000160801, ENSP00000402723, ENST00000313049, ENST00000430002, ENSP00000411424, ENST00000449590

Pharos - Targets

Q03431

Orphanet

15169

ZINC - Predictions - Purchasable

PTH1R_HUMAN

HMDB Protein

HMDBP07958

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.505	4