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PTH1R [plasma membrane]
Stable Identifier
R-HSA-420479
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Parathyroid hormone/parathyroid hormone-related peptide receptor, PTH1R_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH1R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH1R [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH1R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH1R [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH1R [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH1R [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Parathyroid hormone receptor can bind parathyroid hormone (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH1R [plasma membrane] (Homo sapiens)
PTH1R,PTH2R:PTH1R,PTH2R ligands [plasma membrane] (Homo sapiens)
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
PTH1R [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q03431 PTH1R
Gene Names
PTH1R, PTHR, PTHR1
Chain
signal peptide:1-26, chain:27-593
Reference Genes
BioGPS Gene:5745 PTH1R
COSMIC (genes):PTH1R PTH1R
CTD Gene:5745 PTH1R
dbSNP Gene:5745 PTH1R
ENSEMBL:ENSG00000160801 PTH1R
ENSEMBL:ENSG00000160801.14 PTH1R
HGNC:9608 PTH1R
KEGG Gene (Homo sapiens):5745 PTH1R
Monarch:5745 PTH1R
NCBI Gene:5745 PTH1R
OMIM:168468 PTH1R
UCSC:Q03431 PTH1R
Reference Transcript
RefSeq:NM_000316.2 PTH1R
RefSeq:XM_017006933.1 PTH1R
RefSeq:NM_001184744.1 PTH1R
Other Identifiers
11725200_a_at
16940239
205911_PM_at
205911_at
2621033
2621034
2621037
2621038
2621039
2621047
2621052
2621053
2621054
2621055
2621058
2621060
2621061
2621063
2621064
2621065
2621067
2621070
2621073
2621075
2621078
2621079
532_at
533_g_at
5745
8079433
A_23_P167030
GE58971
GO:0001501
GO:0001503
GO:0001701
GO:0002062
GO:0002076
GO:0004888
GO:0004930
GO:0004991
GO:0005515
GO:0005634
GO:0005737
GO:0005886
GO:0005975
GO:0006874
GO:0007165
GO:0007166
GO:0007186
GO:0007187
GO:0007188
GO:0007189
GO:0007200
GO:0008283
GO:0008284
GO:0008285
GO:0016020
GO:0016323
GO:0016324
GO:0017046
GO:0023052
GO:0030154
GO:0030282
GO:0042803
GO:0043226
GO:0043235
GO:0043621
GO:0045453
GO:0048469
GO:0048856
GO:0055065
GO:0060089
GO:0060732
HMNXSV003000208
ILMN_1795166
PH_hs_0000130
PH_hs_0030862
TC03000262.hg
U17418_at
g4506270_3p_at
Participates
as a member of
PTH1R,PTH2R [plasma membrane] (Homo sapiens)
Inferred To
Homologues of PTH1R [plasma membrane]
(Sus scrofa)
pth1ra [plasma membrane]
(Danio rerio)
Pth1r [plasma membrane]
(Mus musculus)
Pth1r [plasma membrane]
(Rattus norvegicus)
pth1r [plasma membrane]
(Xenopus tropicalis)
PTH1R [plasma membrane]
(Bos taurus)
PTH1R [plasma membrane]
(Canis familiaris)
PTH1R [plasma membrane]
(Gallus gallus)
PTH1R [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000307.1
,
NP_001171673.1
,
XP_016862422.1
Guide to Pharmacology - Targets
331
OpenTargets
ENSG00000160801
ZINC - Substances
PTH1R_HUMAN
ZINC target
Q03431
PRO
Q03431
PDB
7VVK
,
7UZP
,
7VVL
,
6NBF
,
7VVM
,
7VVO
,
3H3G
,
5EMB
,
7VVJ
,
3L2J
,
6NBH
,
1BL1
,
3C4M
,
7VVN
,
8HAO
,
4Z8J
,
8HA0
,
6NBI
,
8HAF
HPA
ENSG00000160801-PTH1R
GeneCards
Q03431
Ensembl
ENST00000418619
,
ENSP00000413774
,
ENSP00000321999
,
ENSG00000160801
,
ENSP00000402723
,
ENST00000313049
,
ENST00000430002
,
ENSP00000411424
,
ENST00000449590
Pharos - Targets
Q03431
Orphanet
15169
ZINC - Predictions - Purchasable
PTH1R_HUMAN
HMDB Protein
HMDBP07958
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.505
4
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