Class C/3 (Metabotropic glutamate/pheromone receptors)

Stable Identifier
R-HSA-420499
Type
Pathway
Species
Homo sapiens
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Summation

The class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors (Brauner-Osborne H et al, 2007). Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region.

Literature References
PubMed ID Title Journal Year
12782243 Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

Pin, JP, Galvez, T, Prézeau, L

Pharmacol Ther 2003
17266540 Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors

Brauner-Osborne, H, Wellendorph, P, Jensen, AA

Curr Drug Targets 2007
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