Reactome: A Curated Pathway Database

Opsins act as GEFs for G alpha-t

Stable Identifier
R-HSA-420883
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Transducin (Gt) is a heterotrimeric G protein encoded by GNAT genes and is naturally expressed in vertebrate retina rods and cones. There are two types, alpha-1 chain (expressed in rods by GNAT1) (Lerea CL et al, 1989) and alpha-2 chain (expressed in cones by GNAT2) (Morris TA and Fong SL, 1993). Stimulated opsins can act as GEFs for G (t) alpha subunits by replacing GDP with GTP. Consequently, the G (t) alpha subunit is activated and results in the "vertebrate phototransduction cascade" (Chen CK, 2005). Cyclic GMP Phosphodiesterase is activated which lowers cGMP levels (an intracellular second messenger molecule). Lower cGMP levels can then lead to the closure of cGMP-regulated Na+ and Ca2+ ion channels and a hyperpolarized membrane potential.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
guanyl-nucleotide exchange factor activity of Opsins:photon [photoreceptor disc membrane] Opsins:photon [photoreceptor disc membrane] guanyl-nucleotide exchange factor activity (0005085)
Orthologous Events