Reactome | MyrG-CDK5R1(2-307) [plasma membrane]

MyrG-CDK5R1(2-307) [plasma membrane]

Stable Identifier

R-HSA-421083

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

MyrG-p35, MyrG-CDK5R1, Cyclin-dependent kinase 5 activator 1, CD5R1_HUMAN

Icon

Locations in the PathwayBrowser for interactor UniProt:P43356 MAGA2

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Disease (Homo sapiens)

- Diseases of programmed cell death (Homo sapiens)
  - Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Neurodegenerative Diseases (Homo sapiens)
      - Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
        
        Calpain cleaves p35 to p25 (Homo sapiens)
        
        MyrG-CDK5R1(2-307) [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15078 CDK5R1

Gene Names

CDK5R1, CDK5R, NCK5A

Chain

initiator methionine:, chain:2-307, chain:99-307

Reference Genes

BioGPS Gene:8851 CDK5R1

COSMIC (genes):CDK5R1 CDK5R1

CTD Gene:8851 CDK5R1

dbSNP Gene:8851 CDK5R1

ENSEMBL:ENSG00000176749 CDK5R1

HGNC:1775 CDK5R1

KEGG:hsa:8851 CDK5R1

Monarch:8851 CDK5R1

NCBI Gene:8851 CDK5R1

OMIM:603460 CDK5R1

UCSC:Q15078 CDK5R1

Reference Transcript

Other Identifiers

11722022_s_at

16833159

204995_PM_at

204995_at

204996_PM_s_at

204996_s_at

36273_at

3717776

3717777

3717780

3717781

3717782

3717783

3717784

3717785

3717786

3717788

3717789

55644_at

799_at

8006409

800_g_at

8851

A_14_P109471

A_14_P116589

A_14_P125186

A_23_P141467

A_33_P3226985

GE60061

GO:0000079

GO:0000226

GO:0000307

GO:0001764

GO:0002020

GO:0003779

GO:0003824

GO:0004672

GO:0005509

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0007010

GO:0007155

GO:0007158

GO:0007213

GO:0007411

GO:0007413

GO:0007420

GO:0008092

GO:0009792

GO:0014069

GO:0016020

GO:0016241

GO:0016301

GO:0016533

GO:0016740

GO:0018105

GO:0018107

GO:0019901

GO:0021549

GO:0021722

GO:0021766

GO:0021799

GO:0021819

GO:0030154

GO:0030182

GO:0030295

GO:0030424

GO:0030425

GO:0030426

GO:0031116

GO:0031175

GO:0031594

GO:0032956

GO:0035235

GO:0035255

GO:0042995

GO:0043005

GO:0043014

GO:0043025

GO:0043197

GO:0043204

GO:0043226

GO:0043231

GO:0043292

GO:0043525

GO:0043539

GO:0045296

GO:0045664

GO:0045892

GO:0046875

GO:0048013

GO:0048471

GO:0048487

GO:0048511

GO:0048856

GO:0048870

GO:0051015

GO:0061001

GO:0061575

GO:0070315

GO:0070507

GO:0090314

GO:0098693

GO:0098772

GO:0098793

GO:0140096

HMNXSV003051329

Hs.93597.0.S2_3p_at

ILMN_1730928

ILMN_2062271

PH_hs_0005140

TC17000377.hg

X80343_at

g4502736_3p_a_at

Participates

as an input of

as an output of

as a member of

MyrG-CDK5R1,2 [plasma membrane] (Homo sapiens)

as a component of

Other forms of this molecule

CDK5R1(99-307) [nucleoplasm]

CDK5R1(99-307) [cytosol]

MyrG-CDK5R1(2-98) [plasma membrane]

Inferred To

cdka-1 [plasma membrane] (Caenorhabditis elegans)

Cdk5r1 [plasma membrane] (Rattus norvegicus)

MyrG-CDK5R1(2-307) [plasma membrane] (Gallus gallus)

Cdk5alpha [plasma membrane] (Drosophila melanogaster)

cdk5r1 [plasma membrane] (Xenopus tropicalis)

cdk5r1a [plasma membrane] (Danio rerio)

MyrG-Cdk5r1(2-307) [plasma membrane] (Mus musculus)

CDK5R1 [plasma membrane] (Bos taurus)

CDK5R1 [plasma membrane] (Canis familiaris)

CDK5R1 [plasma membrane] (Sus scrofa)

Modified Residues

Name

N-myristoylglycine at 2

Coordinate

PsiMod Name

N-myristoylglycine [MOD:00068]

PsiMod Definition

A protein modification that effectively converts a glycine residue to N-myristoylglycine.

Cross References

RefSeq

NP_003876.1, XP_011523740.1, XP_016880770.1

OpenTargets

ENSG00000176749

ENSEMBL

ENST00000313401, ENSP00000318486

HPA

ENSG00000176749-CDK5R1

ZINC - Substances

CD5R1_HUMAN

ZINC target

Q15078

PRO

Q15078

Pharos - Targets

Q15078

GlyGen

Q15078

ZINC - Predictions - Purchasable

CD5R1_HUMAN

PDB

3O0G, 6LDP, 7VDP, 7VDR, 1UNL, 7VDQ, 7CNG, 1UNG, 1UNH, 1H4L, 7VDS

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00535 CDK5	4	p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586)	0.94	15
UniProt:Q6ZMQ8-2 AATK			0.593	6
UniProt:P16422 EPCAM	1	EPCAM [plasma membrane] (R-HSA-375068)	0.556	3
UniProt:P26715 KLRC1	1	KLRC1 [plasma membrane] (R-HSA-3006545)	0.556	3
UniProt:Q6UXH1-2 CRELD2			0.556	3
UniProt:Q9NPC7 MYNN			0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:P43356 MAGA2			0.556	3
UniProt:Q9BQ29 Q9BQ29			0.556	3
UniProt:Q9BT49 THAP7			0.556	3
UniProt:A2RUH7 MBPHL			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q8NCR3 MFI			0.556	3
UniProt:P49184 DNASE1L1	2	DNASE1L1 [extracellular region] (R-HSA-6806320) DNASE1L1 [specific granule lumen] (R-HSA-6799554)	0.556	3
UniProt:Q02978 SLC25A11	1	SLC25A11 [mitochondrial inner membrane] (R-HSA-198451)	0.556	3
UniProt:Q96QH2 PRAM			0.556	3
UniProt:Q9HC98-4 NEK6			0.556	3
UniProt:O94983-5 CAMTA2			0.556	3
UniProt:Q96E17 RAB3C	2	GGC-RAB3C [cytosol] (R-HSA-8874012) RAB3C [cytosol] (R-HSA-8873684)	0.556	3
UniProt:Q9ULW0 TPX2	2	TPX2 [nucleoplasm] (R-HSA-2564700) TPX2 [cytosol] (R-HSA-8853407)	0.556	3
UniProt:O43583 DENR			0.527	2
UniProt:Q96EY5 MVB12A	1	MVB12A [endosome membrane] (R-HSA-8955360)	0.527	2
UniProt:Q9NPD8 UBE2T	3	UBE2T [nucleoplasm] (R-HSA-420942) MonoUb-K91,K182-UBE2T [nucleoplasm] (R-HSA-6785362) Ub-C86-UBE2T [nucleoplasm] (R-HSA-8864217)	0.527	2
UniProt:Q01581 HMGCS1	1	HMGCS1 [cytosol] (R-HSA-191329)	0.527	2
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.527	2