Reactome | p-S-ARNTL [nucleoplasm]

p-S-ARNTL [nucleoplasm]

Stable Identifier

R-HSA-421312

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S-BMAL1, p-ARNTL, Aryl hydrocarbon receptor nuclear translocator-like protein 1, phosphorylated, BMAL1_HUMAN, phosphorylated

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Regulation of lipid metabolism by PPARalpha (Homo sapiens)
    - PPARA activates gene expression (Homo sapiens)
      - Expression of PPARA (Homo sapiens)
        
        p-BMAL1:p-CLOCK,NPAS2:PPARA gene [nucleoplasm] (Homo sapiens)
        
        p-BMAL1:p-CLOCK,NPAS2 [nucleoplasm] (Homo sapiens)
        
        p-S-ARNTL [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00327 ARNTL

Gene Names

ARNTL, BHLHE5, BMAL1, MOP3, PASD3

Chain

chain:1-626

Reference Genes

BioGPS Gene:406 ARNTL

COSMIC (genes):ARNTL ARNTL

CTD Gene:406 ARNTL

dbSNP Gene:406 ARNTL

ENSEMBL:ENSG00000133794 ARNTL

ENSEMBL_homo_sapiens_GENE:ENSG00000133794.20 ARNTL

HGNC:701 ARNTL

KEGG Gene (Homo sapiens):406 ARNTL

Monarch:406 ARNTL

NCBI Gene:406 ARNTL

OMIM:602550 ARNTL

UCSC:O00327 ARNTL

Reference Transcript

Other Identifiers

11741091_a_at

11753127_a_at

11755151_a_at

16722217

209824_PM_s_at

209824_s_at

210971_PM_s_at

210971_s_at

3321157

3321158

3321159

3321160

3321173

3321174

3321187

3321193

3321194

3321195

3321197

3321198

3321200

3321201

3321202

3321205

3321206

3321207

3321209

3321210

3321211

3321212

3321213

3321214

3321215

3321216

3321218

3321220

3321225

3321229

3321230

3321231

3321232

3321233

3321234

36896_s_at

406

7938563

AB000816_s_at

A_14_P138600

A_23_P162037

GE54388

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006357

GO:0007283

GO:0007623

GO:0016605

GO:0017162

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0032007

GO:0032922

GO:0033391

GO:0034751

GO:0036211

GO:0042634

GO:0042753

GO:0043161

GO:0043226

GO:0043231

GO:0043565

GO:0045599

GO:0045892

GO:0045893

GO:0045944

GO:0046983

GO:0048511

GO:0048856

GO:0050767

GO:0050796

GO:0051726

GO:0051775

GO:0051879

GO:0070888

GO:0090263

GO:0090403

GO:0120163

GO:0140110

GO:0140297

GO:1901985

GO:1990513

GO:1990837

GO:2000074

GO:2000323

GO:2000772

GO:2001016

HMNXSV003020927

ILMN_1731476

ILMN_2405305

PH_hs_0022167

TC11000206.hg

U60415_at

g2094734_3p_a_at

g2094740_3p_a_at

Participates

as a component of

p-BMAL1:p-CLOCK,NPAS2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

ARNTL [nucleoplasm]

ARNTL [cytosol]

Modified Residues

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_016873231.1, XP_016873237.1, XP_011518414.1, NP_001025443.1, XP_016873236.1, NP_001025444.1, XP_011518415.1, NP_001284651.1, XP_016873235.1, NP_001284648.1, XP_016873232.1, NP_001169.3, NP_001284653.1

OpenTargets

ENSG00000133794

HPA

ENSG00000133794-BMAL1

GeneCards

O00327

Ensembl

ENSP00000433571, ENST00000403510, ENSP00000385897, ENSP00000374357, ENSP00000384517, ENSP00000385915, ENST00000403290, ENST00000529388, ENST00000389707, ENSG00000133794, ENSP00000385581, ENST00000401424, ENST00000403482

PRO

O00327

Pharos - Targets

O00327

PDB

4H10

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15516 CLOCK	3	p-S-CLOCK [nucleoplasm] (R-HSA-421310) CLOCK [cytosol] (R-HSA-400392) CLOCK [nucleoplasm] (R-HSA-879828)	0.731	5
UniProt:D0VY79 D0VY79			0.556	3
UniProt:Q9Y463 DYR1B			0.527	2

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