BMAL1:CLOCK,NPAS2 heterodimer is phosphorylated and translocates to the nucleus

Stable Identifier
R-HSA-421320
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
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Summation

As inferred from mouse, BMAL1 (ARNTL), CLOCK, and NPAS2 are phosphorylated by unknown kinases. The phosphorylation is dependent on the heterodimerization of BMAL1 with CLOCK or NPAS2. Phosphorylated BMAL1:CLOCK/NPAS2 is a much stronger transactivator of gene expression than is unphosphorylated BMAL1:CLOCK/NPAS2.

Participants
Input
Output
Participant Of
hasEvent
Inferred From
Bmal1:Clock,Npas2 heterodimer is phosphorylated and translocates to the nucleus (Mus musculus)
Authored
May, B  (2009-05-18)
Reviewed
D'Eustachio, P  (2009-05-27)
Albrecht, U  (2010-06-23)
Kay, SA  (2010-06-23)
Hirota, T  (2010-06-23)
Delaunay, F  (2010-06-23)