BMAL1:CLOCK,NPAS2 heterodimer is phosphorylated and translocates to the nucleus

Stable Identifier
R-HSA-421320
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Summation

As inferred from mouse, BMAL1 (ARNTL), CLOCK, and NPAS2 are phosphorylated by unknown kinases. The phosphorylation is dependent on the heterodimerization of BMAL1 with CLOCK or NPAS2. Phosphorylated BMAL1:CLOCK/NPAS2 is a much stronger transactivator of gene expression than is unphosphorylated BMAL1:CLOCK/NPAS2.

Participants
Participant Of
hasEvent
Inferred From