BMAL1:CLOCK,NPAS2 heterodimer is phosphorylated and translocates to the nucleus

Stable Identifier
R-HSA-421320
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
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Summation

As inferred from mouse, BMAL1 (ARNTL), CLOCK, and NPAS2 are phosphorylated by unknown kinases. The phosphorylation is dependent on the heterodimerization of BMAL1 with CLOCK or NPAS2. Phosphorylated BMAL1:CLOCK/NPAS2 is a much stronger transactivator of gene expression than is unphosphorylated BMAL1:CLOCK/NPAS2.

Participants
Input
Output
Participant Of
hasEvent
Inferred From
Bmal1:Clock,Npas2 heterodimer is phosphorylated and translocates to the nucleus (Mus musculus)