Cleavage of the signal peptide of Preproghrelin

Stable Identifier
R-HSA-422051
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The N-terminal 23 amino acid residues are cleaved from preproghrelin by the signal peptidase complex. The products are proghrelin (94 amino acid residues) or des-acyl-Gln14 proghrelin (93 amino acid residues), depending on the variant of the mRNA that was translated.

Literature References
PubMed ID Title Journal Year
18396350 Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle

Soares, JB, Leite-Moreira, AF

Peptides 2008
19280057 Ghrelin fluctuation, what determines its production?

Yin, X, Li, Y, Xu, G, An, W, Zhang, W

Acta Biochim Biophys Sin (Shanghai) 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Signal Peptidase [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created