Reactome | SLC4A3 [plasma membrane]

SLC4A3 [plasma membrane]

Stable Identifier

R-HSA-425360

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Anion exchange protein 3, B3A3_HUMAN

Locations in the PathwayBrowser

Expand all

Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
    - Bicarbonate transporters (Homo sapiens)
      - SLC4A1,2,3 exchanges HCO3- for Cl- (Homo sapiens)
        
        SLC4A1,2,3 [plasma membrane] (Homo sapiens)
        
        SLC4A3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48751 SLC4A3

Gene Names

SLC4A3, AE3

Chain

chain:1-1232

Reference Genes

BioGPS Gene:6508 SLC4A3

COSMIC (genes):SLC4A3 SLC4A3

CTD Gene:6508 SLC4A3

dbSNP Gene:6508 SLC4A3

ENSEMBL:ENSG00000114923 SLC4A3

ENSEMBL_homo_sapiens_GENE:ENSG00000114923.17 SLC4A3

HGNC:11029 SLC4A3

KEGG Gene (Homo sapiens):6508 SLC4A3

Monarch:6508 SLC4A3

NCBI Gene:6508 SLC4A3

OMIM:106195 SLC4A3

UCSC:P48751 SLC4A3

Reference Transcript

Other Identifiers

11727689_a_at

11736642_a_at

16891453

205918_PM_at

205918_at

2528775

2528776

2528777

2528778

2528779

2528780

2528781

2528782

2528789

2528790

2528792

2528793

2528794

2528797

2528798

2528799

2528800

2528802

2528803

2528805

2528806

2528807

2528808

2528809

2528810

2528812

2528813

2528815

2528816

2528817

2528818

37489_s_at

37490_at

6508

8048673

A_23_P39647

GE58881

GO:0003013

GO:0005215

GO:0005452

GO:0005515

GO:0005886

GO:0006811

GO:0006820

GO:0008509

GO:0009897

GO:0015106

GO:0015291

GO:0015297

GO:0015698

GO:0015701

GO:0016020

GO:0022853

GO:0022857

GO:0034220

GO:0045851

GO:0051453

GO:0055085

GO:0061337

GO:0086001

GO:0098656

GO:0098660

GO:0098901

GO:0140900

GO:0150104

GO:1902476

HMNXSV003031314

ILMN_1793630

ILMN_1810346

L27213_s_at

PH_hs_0000154

TC02001334.hg

g4827015_3p_at

Participates

as a member of

SLC4A1,2,3 [plasma membrane] (Homo sapiens)

Inferred To

Ae2 [plasma membrane] (Drosophila melanogaster)

SLC4A3 [plasma membrane] (Bos taurus)

SLC4A3 [plasma membrane] (Canis familiaris)

SLC4A3 [plasma membrane] (Gallus gallus)

SLC4A3 [plasma membrane] (Sus scrofa)

slc4a3 [plasma membrane] (Xenopus tropicalis)

Slc4a3 [plasma membrane] (Mus musculus)

Slc4a3 [plasma membrane] (Rattus norvegicus)

abts-4 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_005246846.1, NP_005061.2, NP_001313488.1, NP_963868.2

Guide to Pharmacology - Targets

906

OpenTargets

ENSG00000114923

GeneCards

P48751

HPA

ENSG00000114923-SLC4A3

Ensembl

ENSP00000362865, ENST00000317151, ENSG00000114923, ENST00000273063, ENSP00000273063, ENSP00000350756, ENSP00000314006, ENST00000358055, ENST00000373760

PRO

P48751

Pharos - Targets

P48751

Orphanet

27560

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3