Transport of inorganic cations/anions and amino acids/oligopeptides

Stable Identifier
R-HSA-425393
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+ - and/or Cl- -dependent transport of basic anions [e.g. HCO3-, (CO3)2-] in various tissues and cell types (in addition to pH regulation, specific members of this family also contribute to vectorial trans-epithelial base transport in several organ systems including the kidney, pancreas, and eye) (Pushkin A and Kurtz I, 2006); SLC8 is a group of Na+/Ca2+ exchangers (SLC8A1 is involved in cardiac contractility) (Quednau BD et al, 2004); SLC24 is a group of Na+/Ca2+ or Na+/K+ exchangers (Altimimi HF and Schnetkamp PP, 2007); SLC9 comprises Na+/H+ exchanger proteins involved in the electroneutral exchange of sodium ion and protons (Orlowski J and Grinstein S, 2004); SLC12 functions as Na+, K+ and Cl- ion electroneutral symporters (Hebert SC et al, 2004); SLC26 is the trans-epithelial multifunctional anion (e.g. sulfate, oxalate, HCO-, Cl-) exchanger family, important in cartilage development, production of thyroid hormone, sound amplification in the cochlea etc (Sindic A et al, 2007; Dorwart MR et al, 2008; Ashmore J, 2008). SLC34 is an important Type II Na+/(HPO4)2- symporter (Forster IC et al, 2006; Virkki LV et al, 2007); SLC20 was originally identified as a viral receptor, and functions as a Type III Na+/(H2PO4)- symporter (Collins JF et al, 2004; Virkki LV et al, 2007). Eight SLC gene families are involved in the transport of amino acids and oligopeptides.

Literature References
PubMed ID Title Journal Year
12759754 The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors

Collins, JF, Bai, L, Ghishan, FK

Pflugers Arch 2004
12734757 The sodium/calcium exchanger family-SLC8

Quednau, BD, Nicoll, DA, Philipson, KD

Pflugers Arch 2004
18690016 Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles

Altimimi, HF, Schnetkamp, PP

Channels (Austin) 2007
17581921 Phosphate transporters: a tale of two solute carrier families

Virkki, LV, Biber, J, Murer, H, Forster, IC

Am J Physiol Renal Physiol 2007
12845533 Diversity of the mammalian sodium/proton exchanger SLC9 gene family

Orlowski, J, Grinstein, S

Pflugers Arch 2004
19164095 Analysis and update of the human solute carrier (SLC) gene superfamily

He, L, Vasiliou, K, Nebert, DW

Hum Genomics 2009
17693766 Renal physiology of SLC26 anion exchangers

Sindi?, A, Chang, MH, Mount, DB, Romero, MF

Curr Opin Nephrol Hypertens 2007
18195086 Cochlear outer hair cell motility

Ashmore, J

Physiol Rev 2008
16955105 Proximal tubular handling of phosphate: A molecular perspective

Forster, IC, Hernando, N, Biber, J, Murer, H

Kidney Int 2006
16461757 SLC4 base (HCO3 -, CO3 2-) transporters: classification, function, structure, genetic diseases, and knockout models

Pushkin, A, Kurtz, I

Am J Physiol Renal Physiol 2006
12739168 Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family

Hebert, SC, Mount, DB, Gamba, G

Pflugers Arch 2004
18400693 The solute carrier 26 family of proteins in epithelial ion transport

Dorwart, MR, Shcheynikov, N, Yang, D, Muallem, S

Physiology (Bethesda) 2008
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