Sodium/Calcium exchangers

Stable Identifier
R-HSA-425561
Type
Pathway
Species
Homo sapiens
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Calcium ions are used by cells as ubiquitous signalling molecules that control diverse physiological events. Three mammalian gene families control Ca2+ transport across plasma membranes and intracellular compartments (Lytton J, 2007). They are the Na+/Ca2+ exchanger family designated NCX (SLC8) (three members NCX1-3) (Quednau BD et al, 2004), the Na+/Ca2+-K+ exchanger family designated NCKX (SLC24) (five members NCKX1-5) (Schnetkamp PP, 2004) and a Ca2+/cation exchanger (NCKX6, NCLX) whose physiological function remains unclear.

Literature References
PubMed ID Title Journal Year
14770312 The SLC24 Na+/Ca2+-K+ exchanger family: vision and beyond

Schnetkamp, PP

Pflugers Arch 2004
17716241 Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport

Lytton, J

Biochem J 2007
12734757 The sodium/calcium exchanger family-SLC8

Quednau, BD, Nicoll, DA, Philipson, KD

Pflugers Arch 2004
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