SLC8A1,2,3 exchange 3Na+ for Ca2+

Stable Identifier
R-HSA-425661
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The sodium/calcium exchangers 1, 2 and 3 (SCL8A1,2,3 aka NCX1,2,3) belong to one of three families that control Ca2+ flux across the plasma membrane or intracellular compartments. They extrude Ca2+ from the cell, using the electrochemical gradient of Na+ as it flows into the cell. One Ca2+ is exchanged for three Na+. During this electrogenic exchange, the membrane potential is altered. SLC8A1, 2, 3 play a minor role during phase 2, since they begin to restore ion concentrations. The high concentration of intracellular calcium starts contraction of those cells, which is sustained in the plateau phase. SLC8A1 has a ubiquitous expression profile (highest expression in heart, brain and kidney) and was originally cloned and characterized from human cardiac muscle (Komuro et al. 1992). Both SLC8A2) (Li et al. 1994) and SLC8A3 (Gabellini et al. 2002) are expressed in the brain.
In Rabbits, sorcin (SRI) activates SLC8A1, via the interaction of the respective Ca2+-binding domains (Zamparelli et al. 2010). Calmodulin (CALM1) binds to the cytoplasmic loop of NCX1 to negatively regulate exchange activity (Chou et al. 2015).

Literature References
PubMed ID Title Journal Year
20298697 Activation of the cardiac Na(+)-Ca(2+) exchanger by sorcin via the interaction of the respective Ca(2+)-binding domains

Zamparelli, C, Macquaide, N, Colotti, G, Verzili, D, Seidler, T, Smith, GL, Chiancone, E

J. Mol. Cell. Cardiol. 2010
1374913 Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA

Komuro, I, Wenninger, KE, Philipson, KD, Izumo, S

Proc Natl Acad Sci U S A 1992
8021246 Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger

Li, Z, Matsuoka, S, Hryshko, LV, Nicoll, DA, Bersohn, MM, Burke, EP, Lifton, RP, Philipson, KD

J Biol Chem 1994
26421717 Calmodulin Interacts with the Sodium/Calcium Exchanger NCX1 to Regulate Activity

Chou, AC, Ju, YT, Pan, CY

PLoS ONE 2015
12406570 The human SLC8A3 gene and the tissue-specific Na+/Ca2+ exchanger 3 isoforms

Gabellini, N, Bortoluzzi, S, Danieli, GA, Carafoli, E

Gene 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calcium:sodium antiporter activity of SLC8A1,2,3 [plasma membrane]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created