K+-independent Li+/Ca2+ exchanger transport

Stable Identifier
R-HSA-425822
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
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Summation

SLC24A6 (NCKX6, NCLX) (Palty R et al, 2004) encodes a protein which can transport Li+ or Na+ in exchange for Ca2+ in an K+-independent manner (Cai X and Lytton J, 2004). Lithium exchange with calcium is shown here.

Literature References
PubMed ID Title Journal Year
14625281 Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6

Cai, X, Lytton, J

J Biol Chem 2004
15060069 Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger

Palty, R, Ohana, E, Hershfinkel, M, Volokita, M, Elgazar, V, Beharier, O, Silverman, WF, Argaman, M, Sekler, I

J Biol Chem 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
calcium:cation antiporter activity of SLC24A6 [plasma membrane]
Physical Entity
SLC24A6 [plasma membrane]
Activity
calcium:cation antiporter activity (0015368)
Orthologous Events
K+-independent Li+/Ca2+ exchanger transport (Arabidopsis thaliana)
K+-independent Li+/Ca2+ exchanger transport (Bos taurus)
K+-independent Li+/Ca2+ exchanger transport (Caenorhabditis elegans)
K+-independent Li+/Ca2+ exchanger transport (Canis familiaris)
K+-independent Li+/Ca2+ exchanger transport (Danio rerio)
K+-independent Li+/Ca2+ exchanger transport (Drosophila melanogaster)
K+-independent Li+/Ca2+ exchanger transport (Gallus gallus)
K+-independent Li+/Ca2+ exchanger transport (Mus musculus)
K+-independent Li+/Ca2+ exchanger transport (Oryza sativa)
K+-independent Li+/Ca2+ exchanger transport (Rattus norvegicus)
K+-independent Li+/Ca2+ exchanger transport (Schizosaccharomyces pombe)
K+-independent Li+/Ca2+ exchanger transport (Sus scrofa)
K+-independent Li+/Ca2+ exchanger transport (Taeniopygia guttata)
K+-independent Li+/Ca2+ exchanger transport (Xenopus tropicalis)
Authored
Jassal, B  (2009-06-08)
Reviewed
He, L  (2009-08-24)