SLC9A6,7 exchange Na+ for H+ across the early endosome membrane

Stable Identifier
R-HSA-425983
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Na+/H+ exchanger transport (at early endosome membrane)
Locations in the PathwayBrowser
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NHE6 (SLC9A6) (Brett CL et al, 2002; Nakamura N et al, 2005) is expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in early endosomes.

Literature References
PubMed ID Title Journal Year
15522866 Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation

Nakamura, N, Tanaka, S, Teko, Y, Mitsui, K, Kanazawa, H

J Biol Chem 2005
11940519 Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria

Brett, CL, Wei, Y, Donowitz, M, Rao, R

Am J Physiol Cell Physiol 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sodium:proton antiporter activity of SLC9A6,7 [early endosome membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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