Na+/H+ exchanger transport (at cell membrane)

Stable Identifier
R-HSA-425994
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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NHE1 (SLC9A1) is present in most cells and is the most extensively characterized member of this family (Sardet C et al, 1989). NHE2-4 (SLC9A2-4) (Malakooti J et al, 1999; Brant SR et al, 1995) are expressed mainly in the kidney and GI tract. NHE5 (SLC9A5) (Baird NR et al, 1999) is highly expressed in neuronal-enriched areas of the CNS.

Literature References
PubMed ID Title Journal Year
9933641 Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain

Baird, NR, Orlowski, J, Szabó, EZ, Zaun, HC, Schultheis, PJ, Menon, AG, Shull, GE

J Biol Chem 1999
10444453 Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2

Malakooti, J, Dahdal, RY, Schmidt, L, Layden, TJ, Dudeja, PK, Ramaswamy, K

Am J Physiol 1999
7631746 Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3

Brant, SR, Yun, CH, Donowitz, M, Tse, CM

Am J Physiol 1995
2536298 Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter

Sardet, C, Franchi, A, Pouysségur, J

Cell 1989
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sodium:proton antiporter activity of SLC9A1-5 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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