Arachidonate production from DAG

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R-HSA-426048
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Pathway
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Homo sapiens
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Diacylglycerol (DAG) is an important source of arachidonic acid, a signalling molecule and the precursor of the prostaglandins. In human platelet almost all the DAG produced from phosphatidylinositol degradation contains arachidonate (Takamura et al. 1987). DAG is hydrolysed by DAG lipase to 2-arachidonylglycerol (2-AG) which is further hydrolysed by monoacylglycerol lipase. 2-AG is an agonist of cannabinoid receptor 1.

Literature References
PubMed ID Title Journal Year
6788766 Diacylglycerol metabolism and arachidonic acid release in human fetal membranes and decidua vera

Okazaki, T, Sagawa, N, Okita, JR, Bleasdale, JE, MacDonald, PC, Johnston, JM

J Biol Chem 1981
7295321 Release of arachidonate from diglyceride in human platelets requires the sequential action of a diglyceride lipase and a monoglyceride lipase

Chau, LY, Tai, HH

Biochem Biophys Res Commun 1981
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