Two genes (SLC12A1 and SLC12A2) encode Na+,K+/2Cl- cotransporters (NKCC2 and NKCC1 respectively). SLC12A1 (Simon DB et al, 1996) is kidney-specific whilst SLC12A2 (Payne JA et al, 1995) is ubiquitously expressed. Two Cl- ions are electroneutrally transported into cells with a Na+ ion and a K+ ion.
Simon, DB, Karet, FE, Hamdan, JM, DiPietro, A, Sanjad, SA, Lifton, RP
Payne, JA, Xu, JC, Haas, M, Lytle, CY, Ward, D, Forbush B, 3rd
© 2021 Reactome