SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol

Stable Identifier
R-HSA-426086
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Na+, K+/2Cl- cotransport
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Two genes (SLC12A1 and SLC12A2) encode Na+,K+/2Cl- cotransporters (NKCC2 and NKCC1 respectively). SLC12A1 (Simon DB et al, 1996) is kidney-specific whilst SLC12A2 (Payne JA et al, 1995) is ubiquitously expressed. Two Cl- ions are electroneutrally transported into cells with a Na+ ion and a K+ ion.

Literature References
PubMed ID Title Journal Year
8640224 Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2

Simon, DB, Karet, FE, Hamdan, JM, DiPietro, A, Sanjad, SA, Lifton, RP

Nat Genet 1996
7629105 Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon

Payne, JA, Xu, JC, Haas, M, Lytle, CY, Ward, D, Forbush B, 3rd

J Biol Chem 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sodium:potassium:chloride symporter activity of SLC12A1,2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
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Created
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