DAG activation of TRPC channels

Stable Identifier
R-HSA-426209
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

TRPC3, 6 and 7 are non-selective cation channels that are activated by diacylglycerol (DAG) independently of protein kinase C activation by DAG. By analogy with the structures of voltage-regulated calcium channels, TRPC channels are probably tetramers of TRPC protein; heterotetramers within the 3/6/7 group have been observed.

Literature References
PubMed ID Title Journal Year
9930701 Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

Hofmann, T, Obukhov, AG, Schaefer, M, Harteneck, C, Gudermann, T, Schultz, G

Nature 1999
11805119 Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx

Riccio, A, Mattei, C, Kelsell, RE, Medhurst, AD, Calver, AR, Randall, AD, Davis, JB, Benham, CD, Pangalos, MN

J Biol Chem 2002
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