Reactome | Cation influx mediated by TRPC3/6/7

Cation influx mediated by TRPC3/6/7

Stable Identifier

R-HSA-426223

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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TRP channels are non-selectively permeable to cations, allowing enty into the cell via concentration gradients. All mammalian TRPCs require PLC for activation.

Literature References

PubMed ID	Title	Journal	Year
8646775	trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry Peyton, M, Stefani, E, Jiang, M, Boulay, G, Birnbaumer, L, Hurst, R, Zhu, X	Cell	1996
11805119	Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx Randall, AD, Riccio, A, Davis, JB, Mattei, C, Benham, CD, Medhurst, AD, Calver, AR, Kelsell, RE, Pangalos, MN	J Biol Chem	2002
9930701	Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol Schultz, G, Hofmann, T, Harteneck, C, Gudermann, T, Obukhov, AG, Schaefer, M	Nature	1999