DAG kinase produces phosphatidic acid from DAG

Stable Identifier
R-HSA-426240
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
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Summation

Diacylglycerol kinases (DGKs) are intracellular lipid kinases that use ATP to phosphorylate diacylglycerol (DAG)., generating phosphatidic acid (PA). This lowers membrane DAG levels, regulating signalling proteins that require DAG for membrane association such as Protein Kinase C. PA is a signalling molecule that regulates Raf-1 and PKC zeta, and a substrate for the resynthesis of phosphatidylinositol.

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
diacylglycerol kinase activity of Diacylglycerol kinase [plasma membrane]
Physical Entity
Diacylglycerol kinase [plasma membrane]
Activity
diacylglycerol kinase activity (0004143)
Orthologous Events
DAG kinase produces phosphatidic acid from DAG (Arabidopsis thaliana)
DAG kinase produces phosphatidic acid from DAG (Bos taurus)
DAG kinase produces phosphatidic acid from DAG (Caenorhabditis elegans)
DAG kinase produces phosphatidic acid from DAG (Canis familiaris)
DAG kinase produces phosphatidic acid from DAG (Danio rerio)
DAG kinase produces phosphatidic acid from DAG (Dictyostelium discoideum)
DAG kinase produces phosphatidic acid from DAG (Drosophila melanogaster)
DAG kinase produces phosphatidic acid from DAG (Gallus gallus)
DAG kinase produces phosphatidic acid from DAG (Mus musculus)
DAG kinase produces phosphatidic acid from DAG (Oryza sativa)
DAG kinase produces phosphatidic acid from DAG (Rattus norvegicus)
DAG kinase produces phosphatidic acid from DAG (Sus scrofa)
DAG kinase produces phosphatidic acid from DAG (Taeniopygia guttata)
DAG kinase produces phosphatidic acid from DAG (Xenopus tropicalis)