DAG kinase produces phosphatidic acid from DAG

Stable Identifier
R-HSA-426240
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Diacylglycerol kinases (DGKs) are intracellular lipid kinases that use ATP to phosphorylate diacylglycerol (DAG)., generating phosphatidic acid (PA). This lowers membrane DAG levels, regulating signalling proteins that require DAG for membrane association such as Protein Kinase C. PA is a signalling molecule that regulates Raf-1 and PKC zeta, and a substrate for the resynthesis of phosphatidylinositol.

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Catalyst Activity
Title
diacylglycerol kinase activity of Diacylglycerol kinase [plasma membrane]
Physical Entity
Activity
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