Reactome: A Curated Pathway Database

DAG kinase produces phosphatidic acid from DAG

Stable Identifier
R-HSA-426240
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Diacylglycerol kinases (DGKs) are intracellular lipid kinases that use ATP to phosphorylate diacylglycerol (DAG)., generating phosphatidic acid (PA). This lowers membrane DAG levels, regulating signalling proteins that require DAG for membrane association such as Protein Kinase C. PA is a signalling molecule that regulates Raf-1 and PKC zeta, and a substrate for the resynthesis of phosphatidylinositol.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
diacylglycerol kinase activity of Diacylglycerol kinase [plasma membrane] Diacylglycerol kinase [plasma membrane] diacylglycerol kinase activity (0004143)
Orthologous Events