TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.

Stable Identifier
R-HSA-427336
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
TTF-I;rRNA Promoter:CSB:G9a Complex Dimethylates Histone H3 at lysine-9
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TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
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As inferred from mouse, EHMT2 (histone methyltransferase G9a) dimethylates histone H3 at lysine-9 (H3K9me2) in the transcribed region of the rRNA gene. Dimethylation of histone H3 in the transcribed region causes increased rRNA expression, which contrasts with the repressive effect of H3K9me2 in other regions of the genome. The histone binding activity and ATPase activity of CHD4 in the NuRD complex are also needed for activation.

Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
histone methyltransferase activity (H3-K9 specific) of TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm]
Physical Entity
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm]
Activity
histone methyltransferase activity (H3-K9 specific) (0046974)
Inferred From
Ttf-I:rRNA Promoter:Ercc6:Ehmt2 complex dimethylates histone H3 at lysine-9 (Homo sapiens)
Authored
May, B  (2009-06-21)
Reviewed
Iben, S  (2016-02-12)
Created
May, B  (2009-06-20)
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