Reactome | MBD2 [nucleoplasm]

MBD2 [nucleoplasm]

Stable Identifier

R-HSA-427367

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Methyl-CpG-binding domain protein 2, MBD2_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:O14519 CDKA1

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External Reference Information

External Reference

UniProt:Q9UBB5 MBD2

Gene Names

MBD2

Chain

chain:1-411

Reference Genes

BioGPS Gene:8932 MBD2

COSMIC (genes):MBD2 MBD2

CTD Gene:8932 MBD2

dbSNP Gene:8932 MBD2

ENSEMBL:ENSG00000134046 MBD2

HGNC:6917 MBD2

Monarch:8932 MBD2

NCBI Gene:8932 MBD2

OMIM:603547 MBD2

UCSC:Q9UBB5 MBD2

Reference Transcript

Other Identifiers

11731288_a_at

11731289_at

11734687_at

11734688_at

16855329

202484_PM_s_at

202484_s_at

202485_PM_s_at

202485_s_at

214396_PM_s_at

214396_s_at

214397_PM_at

214397_at

33905_at

3808598

3808599

3808601

3808602

3808603

3808605

3808606

3808608

3808609

3808618

3808619

3808622

3808623

3808625

3808635

3808636

3808637

3808638

3808639

57007_at

8023382

8932

A_23_P15864

A_24_P119201

A_32_P107777

GE82035

GE851413

GO:0000118

GO:0000122

GO:0000785

GO:0000792

GO:0003229

GO:0003677

GO:0003682

GO:0003696

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006346

GO:0006355

GO:0008327

GO:0009612

GO:0014070

GO:0016055

GO:0016581

GO:0019904

GO:0022414

GO:0030177

GO:0031492

GO:0031667

GO:0032355

GO:0032991

GO:0035197

GO:0040029

GO:0042127

GO:0042711

GO:0042802

GO:0043226

GO:0045892

GO:0045893

GO:0048568

GO:0048856

GO:0060090

GO:0065003

GO:0070742

GO:0071407

HMNXSV003015462

HMNXSV003040940

Hs.25674.2.S1_3p_a_at

Hs.25674.2.S1_3p_at

ILMN_1717195

ILMN_1750395

ILMN_1785587

ILMN_2387452

PH_hs_0031098

TC18000521.hg

g3800792_3p_a_at

g7710146_3p_a_at

Participates

as an input of

MBD2 binds methylcytosine in chromatin (Homo sapiens)

as a component of

Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm] (Homo sapiens)

Inferred To

Homologues of MBD2 [nucleoplasm] (Danio rerio)

Ghost homologue of MBD2 [nucleoplasm] (Gallus gallus)

Mbd2 [nucleoplasm] (Mus musculus)

Mbd2 [nucleoplasm] (Rattus norvegicus)

MBD-like [nucleoplasm] (Drosophila melanogaster)

mbd3a [nucleoplasm] (Danio rerio)

mbd2 [nucleoplasm] (Danio rerio)

MBD2 [nucleoplasm] (Bos taurus)

MBD2 [nucleoplasm] (Canis familiaris)

MBD2 [nucleoplasm] (Sus scrofa)

mbd1b [nucleoplasm] (Danio rerio)

mbd3 [nucleoplasm] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000134046

ENSEMBL

ENSP00000256429, ENSP00000464554, ENST00000256429, ENST00000583046

HPA

ENSG00000134046-MBD2

PRO

Q9UBB5

Pharos - Targets

Q9UBB5

PDB

6C1A, 7AOA, 7AO9, 6C2F, 2L2L, 6C1T, 6C1U, 6CNQ, 7MWK, 6CNP, 6C1V, 7AO8, 7RAY, 7MWM

HMDB Protein

HMDBP02250

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.894	10
UniProt:Q86YP4 GATAD2A	1	GATAD2A [nucleoplasm] (R-HSA-3702077)	0.876	10
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.788	5
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.725	6
UniProt:O14519 CDKA1			0.643	4
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.643	5
IntAct:EBI-16803739 17BP			0.558	4
UniProt:Q96QR8 PURB			0.556	3
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.527	4
UniProt:Q9P2Y4 ZN219			0.527	4
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.508	2
UniProt:P26358 DNMT1	2	DNMT1 [nucleoplasm] (R-HSA-212181) monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.462	3