eNoSC deacetylates histone H3

Stable Identifier
R-HSA-427514
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The Sirtuin-1 (SIRT1) component of eNoSC deacetylates histone H3 at lysine-9 (Vaquero et al. 2004, Murayama et al. 2008). The reaction uses nicotinamide adenine dinucleotide (NAD) as the acceptor of the acetyl group and generates nicotinamide and 1-O-acetyl-ADP-ribose as products (Vaquero et al. 2004). The use of NAD links the reaction to the overall energy balance of the cell. Cells exposed to high glucose have a greater NADH:NAD ratio and therefore lower activity of eNoSC (Murayama et al. 2008). Low glucose produces higher NAD and higher activity of eNoSC.

Literature References
PubMed ID Title Journal Year
15469825 Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

Vaquero, A, Scher, M, Lee, D, Erdjument-Bromage, H, Tempst, P, Reinberg, D

Mol. Cell 2004
18485871 Epigenetic control of rDNA loci in response to intracellular energy status

Murayama, A, Ohmori, K, Fujimura, A, Minami, H, Yasuzawa-Tanaka, K, Kuroda, T, Oie, S, Daitoku, H, Okuwaki, M, Nagata, K, Fukamizu, A, Kimura, K, Shimizu, T, Yanagisawa, J

Cell 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone deacetylase activity of eNoSC [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created