eNoSC dimethylates histone H3 at lysine-9

Stable Identifier
R-HSA-427527
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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eNoSC dimethylates histone H3 at lysine-9
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The SUV39H1 component of eNoSC dimethylates histone H3 at lysine-9 (Murayama et al. 2008). The reaction depends on the prior deacetylation reaction catalyzed by the SIRT1 component of eNoSC. Histone H3 dimethylated at lysine-9 inhibits expression of rRNA genes.

Literature References
PubMed ID Title Journal Year
18485871 Epigenetic control of rDNA loci in response to intracellular energy status

Murayama, A, Ohmori, K, Fujimura, A, Minami, H, Yasuzawa-Tanaka, K, Kuroda, T, Oie, S, Daitoku, H, Okuwaki, M, Nagata, K, Fukamizu, A, Kimura, K, Shimizu, T, Yanagisawa, J

Cell 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
histone methyltransferase activity (H3-K9 specific) of eNoSC [nucleoplasm]
Physical Entity
eNoSC [nucleoplasm]
Activity
histone methyltransferase activity (H3-K9 specific) (0046974)
Orthologous Events
eNoSC dimethylates histone H3 at lysine-9 (Bos taurus)
eNoSC dimethylates histone H3 at lysine-9 (Caenorhabditis elegans)
eNoSC dimethylates histone H3 at lysine-9 (Canis familiaris)
eNoSC dimethylates histone H3 at lysine-9 (Danio rerio)
eNoSC dimethylates histone H3 at lysine-9 (Drosophila melanogaster)
eNoSC dimethylates histone H3 at lysine-9 (Mus musculus)
eNoSC dimethylates histone H3 at lysine-9 (Rattus norvegicus)
eNoSC dimethylates histone H3 at lysine-9 (Sus scrofa)
Authored
May, B  (2009-06-22)
Reviewed
Voit, R  (2014-01-21)
Grummt, I  (2014-01-21)
Created
May, B  (2009-06-23)