eNoSC dimethylates histone H3 at lysine-9

Stable Identifier
R-HSA-427527
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The SUV39H1 component of eNoSC dimethylates histone H3 at lysine-9 (Murayama et al. 2008). The reaction depends on the prior deacetylation reaction catalyzed by the SIRT1 component of eNoSC. Histone H3 dimethylated at lysine-9 inhibits expression of rRNA genes.

Literature References
PubMed ID Title Journal Year
18485871 Epigenetic control of rDNA loci in response to intracellular energy status

Murayama, A, Ohmori, K, Fujimura, A, Minami, H, Yasuzawa-Tanaka, K, Kuroda, T, Oie, S, Daitoku, H, Okuwaki, M, Nagata, K, Fukamizu, A, Kimura, K, Shimizu, T, Yanagisawa, J

Cell 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone methyltransferase activity (H3-K9 specific) of eNoSC [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created