Reactome | eNoSC dimethylates histone H3 at lysine-9

eNoSC dimethylates histone H3 at lysine-9

Stable Identifier

R-HSA-427527

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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The SUV39H1 component of eNoSC dimethylates histone H3 at lysine-9 (Murayama et al. 2008). The reaction depends on the prior deacetylation reaction catalyzed by the SIRT1 component of eNoSC. Histone H3 dimethylated at lysine-9 inhibits expression of rRNA genes.

Literature References

PubMed ID	Title	Journal	Year
18485871	Epigenetic control of rDNA loci in response to intracellular energy status Murayama, A, Ohmori, K, Fujimura, A, Minami, H, Yasuzawa-Tanaka, K, Kuroda, T, Oie, S, Daitoku, H, Okuwaki, M, Nagata, K, Fukamizu, A, Kimura, K, Shimizu, T, Yanagisawa, J	Cell	2008