eNoSC dimethylates histone H3 at lysine-9

Stable Identifier
R-HSA-427527
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The SUV39H1 component of eNoSC dimethylates histone H3 at lysine-9 (Murayama et al. 2008). The reaction depends on the prior deacetylation reaction catalyzed by the SIRT1 component of eNoSC. Histone H3 dimethylated at lysine-9 inhibits expression of rRNA genes.
Literature References
PubMed ID Title Journal Year
18485871 Epigenetic control of rDNA loci in response to intracellular energy status

Fujimura, A, Murayama, A, Minami, H, Nagata, K, Kuroda, T, Kimura, K, Oie, S, Ohmori, K, Yasuzawa-Tanaka, K, Daitoku, H, Yanagisawa, J, Fukamizu, A, Okuwaki, M, Shimizu, T

Cell 2008
Participants
Participates
Catalyst Activity

histone methyltransferase activity (H3-K9 specific) of eNoSC [nucleoplasm]

Orthologous Events
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