Reactome | SIRT1 [nucleoplasm]

SIRT1 [nucleoplasm]

Stable Identifier

R-HSA-427531

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NAD-dependent deacetylase sirtuin-1, SIRT1_HUMAN

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External Reference Information

External Reference

UniProt:Q96EB6 SIRT1

Gene Names

SIRT1, SIR2L1

Chain

initiator methionine:1, chain:2-747, chain:2-533

Reference Genes

BioGPS Gene:23411 SIRT1

COSMIC (genes):SIRT1 SIRT1

CTD Gene:23411 SIRT1

dbSNP Gene:23411 SIRT1

ENSEMBL:ENSG00000096717 SIRT1

ENSEMBL:ENSG00000096717.12 SIRT1

HGNC:14929 SIRT1

KEGG Gene (Homo sapiens):23411 SIRT1

Monarch:23411 SIRT1

NCBI Gene:23411 SIRT1

OMIM:604479 SIRT1

UCSC:Q96EB6 SIRT1

Reference Transcript

Other Identifiers

11726140_s_at

11749703_a_at

16705313

218878_PM_s_at

218878_s_at

23411

3249588

3249589

3249590

3249591

3249592

3249593

3249594

3249595

3249596

3249597

3249603

3249604

3249605

3249606

3249607

3249611

3249612

3249613

3249614

3249615

46399_at

61678_at

64265_s_at

7927814

A_14_P102363

A_14_P139914

A_23_P98022

GE79125

GO:0000012

GO:0000122

GO:0000183

GO:0000278

GO:0000720

GO:0000731

GO:0000785

GO:0000791

GO:0000792

GO:0000978

GO:0001525

GO:0001542

GO:0001650

GO:0001678

GO:0001934

GO:0001938

GO:0002039

GO:0002376

GO:0002821

GO:0003677

GO:0003713

GO:0003714

GO:0003824

GO:0004407

GO:0004857

GO:0005515

GO:0005634

GO:0005635

GO:0005637

GO:0005654

GO:0005677

GO:0005694

GO:0005730

GO:0005737

GO:0005739

GO:0005829

GO:0005975

GO:0006281

GO:0006325

GO:0006346

GO:0006351

GO:0006355

GO:0006476

GO:0006629

GO:0006642

GO:0006914

GO:0006915

GO:0006974

GO:0006979

GO:0007010

GO:0007179

GO:0007283

GO:0007346

GO:0007517

GO:0007623

GO:0008047

GO:0008284

GO:0008630

GO:0009267

GO:0010629

GO:0010824

GO:0010868

GO:0010875

GO:0010883

GO:0010906

GO:0012501

GO:0014068

GO:0016239

GO:0016567

GO:0016575

GO:0016605

GO:0016740

GO:0016787

GO:0016922

GO:0017136

GO:0018394

GO:0019212

GO:0019213

GO:0019899

GO:0019904

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0030225

GO:0030308

GO:0030512

GO:0031062

GO:0031065

GO:0031393

GO:0031507

GO:0031648

GO:0032007

GO:0032071

GO:0032088

GO:0032868

GO:0032922

GO:0032991

GO:0033210

GO:0033553

GO:0033558

GO:0034391

GO:0034979

GO:0034983

GO:0035098

GO:0035356

GO:0035358

GO:0036211

GO:0042127

GO:0042149

GO:0042326

GO:0042393

GO:0042542

GO:0042595

GO:0042632

GO:0042771

GO:0042802

GO:0042981

GO:0043065

GO:0043066

GO:0043124

GO:0043161

GO:0043226

GO:0043280

GO:0043398

GO:0043425

GO:0043433

GO:0043518

GO:0043524

GO:0043536

GO:0044321

GO:0045348

GO:0045599

GO:0045722

GO:0045739

GO:0045766

GO:0045786

GO:0045892

GO:0045944

GO:0046015

GO:0046628

GO:0046872

GO:0046969

GO:0048511

GO:0048856

GO:0048870

GO:0050872

GO:0051019

GO:0051097

GO:0051152

GO:0051658

GO:0051898

GO:0055089

GO:0060766

GO:0060907

GO:0061773

GO:0070301

GO:0070403

GO:0070857

GO:0070914

GO:0070932

GO:0071356

GO:0071456

GO:0071479

GO:0071900

GO:0090335

GO:0090400

GO:0097009

GO:0098772

GO:0106230

GO:0106231

GO:0140096

GO:0140110

GO:0140297

GO:0140537

GO:0140677

GO:0160011

GO:0160012

GO:1900034

GO:1900113

GO:1901984

GO:1902166

GO:1902176

GO:1902237

GO:1904179

GO:1990254

GO:1990830

GO:1990841

GO:2000111

GO:2000480

GO:2000481

GO:2000655

GO:2000757

GO:2000773

GO:2000774

GO:2000781

HMNXSV003017292

HMNXSV003032123

ILMN_1739083

PH_hs_0002658

TC10000400.hg

g13775598_3p_a_at

Participates

as an input of

as a component of

as an output of

SIRT1 deacetylates HSF1 (Homo sapiens)

as a member of

SIRT1,SIRT3 [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

Inferred To

Homologues of SIRT1 [nucleoplasm] (Rattus norvegicus)

SIRT1 [nucleoplasm] (Bos taurus)

SIRT1 [nucleoplasm] (Caenorhabditis elegans)

SIRT1 [nucleoplasm] (Canis familiaris)

SIRT1 [nucleoplasm] (Danio rerio)

SIRT1 [nucleoplasm] (Dictyostelium discoideum)

SIRT1 [nucleoplasm] (Drosophila melanogaster)

SIRT1 [nucleoplasm] (Gallus gallus)

SIRT1 [nucleoplasm] (Mus musculus)

SIRT1 [nucleoplasm] (Rattus norvegicus)

SIRT1 [nucleoplasm] (Saccharomyces cerevisiae)

SIRT1 [nucleoplasm] (Schizosaccharomyces pombe)

SIRT1 [nucleoplasm] (Sus scrofa)

SIRT1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001135970.1, NP_001300978.1, NP_036370.2

Guide to Pharmacology - Targets

2707

OpenTargets

ENSG00000096717

ZINC - Substances

SIR1_HUMAN

ZINC - Biogenic

SIR1_HUMAN

ZINC target

Q96EB6

PRO

Q96EB6

PDB

4ZZH, 4IF6, 4I5I, 4IG9, 5BTR, 4KXQ, 4ZZI, 4ZZJ

ZINC - Investigational

SIR1_HUMAN

HPA

ENSG00000096717-SIRT1

GeneCards

Q96EB6

Ensembl

ENSP00000212015, ENST00000212015, ENSG00000096717

Pharos - Targets

Q96EB6

ZINC - Predictions - Purchasable

SIR1_HUMAN

Orphanet

24903

HMDB Protein

HMDBP08879

Interactors (56)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.957	18
UniProt:P68400 CSNK2A1	2	CSNK2A1 [nucleoplasm] (R-HSA-6805057) CSNK2A1 [cytosol] (R-HSA-201713)	0.77	5
UniProt:Q8N163 CCAR2	2	DBC1 [nucleoplasm] (R-HSA-3371479) p-T454-DBC1 [nucleoplasm] (R-HSA-3371569)	0.769	16
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.761	9
UniProt:P26358 DNMT1	2	monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353) DNMT1 [nucleoplasm] (R-HSA-212181)	0.752	11
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.734	4
UniProt:Q86WX3 RPS19BP1	1	RPS19BP1 [nucleoplasm] (R-HSA-3371427)	0.733	11
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.729	5
UniProt:O43524 FOXO3	9	p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S215 FOXO3 [cytosol] (R-HSA-5687014) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) FOXO3 [nucleoplasm] (R-HSA-199305)	0.704	5
UniProt:Q12778 FOXO1	5	p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651) FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942)	0.702	4
UniProt:Q8WTS6 SETD7	1	SETD7 [nucleoplasm] (R-HSA-1183221)	0.668	11
UniProt:P12956 XRCC6	5	XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [nucleoplasm] (R-HSA-58272)	0.667	7
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.656	3
UniProt:Q9Y5P2 CSAG2			0.644	8
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.639	7
UniProt:O60934 NBN	3	p-S343-NBN [nucleoplasm] (R-HSA-75237) NBN [nucleoplasm] (R-HSA-75163) NBN [cytosol] (R-HSA-5684005)	0.632	5
UniProt:P67870 CSNK2B	5	CSNK2B [secretory granule lumen] (R-HSA-6801319) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [cytosol] (R-HSA-201693)	0.626	5
UniProt:P27695 APEX1	1	APEX1 [nucleoplasm] (R-HSA-50119)	0.619	6
UniProt:Q15466 NR0B2	1	NR0B2 [nucleoplasm] (R-HSA-376312)	0.61	6
UniProt:O15350 TP73	3	PolyUb-TP73 [cytosol] (R-HSA-8957256) TP73 [cytosol] (R-HSA-8957239) TP73 [nucleoplasm] (R-HSA-6798094)	0.602	4
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.602	5
UniProt:O95352 ATG7	14	ATG7 [secretory granule lumen] (R-HSA-6801316) ATG7 [extracellular region] (R-HSA-6806451) ATG7 [ficolin-1-rich granule lumen] (R-HSA-6801293) ATG7(1-693)-BRAF(381-766) fusion [cytosol] (R-HSA-6802272) ATG7(1-693)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802517) CysO572-ATG7-MAP1LC3B [cytosol] (R-HSA-9820410) CysO572-ATG7-GARABAPL2 [cytosol] (R-HSA-9820413) CysO572-ATG7-GARABAP [cytosol] (R-HSA-9820417) CysO572-ATG7-GARABAPL1 [cytosol] (R-HSA-9820406) CysO572-ATG7-MAP1LC3C [cytosol] (R-HSA-9820407) CysO572-ATG7-MAP1LC3A [cytosol] (R-HSA-9820421) CysO572-ATG7-GARABAPL3 [cytosol] (R-HSA-9820420) CysO572-ATG7 [cytosol] (R-HSA-5683584) ATG7 [cytosol] (R-HSA-947867)	0.602	3
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.602	8
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.602	4
UniProt:Q9UBC3 DNMT3B	2	SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334) DNMT3B [nucleoplasm] (R-HSA-212316)	0.597	4
UniProt:Q9HAN9 NMNAT1	1	NMNAT1 [nucleoplasm] (R-HSA-200484)	0.591	3
UniProt:Q13085 ACACA	2	Btn-ACACA [cytosol] (R-HSA-2976730) ACACA [cytosol] (R-HSA-1660609)	0.591	3
UniProt:Q9Y4H2 IRS2	4	IRS2 [plasma membrane] (R-HSA-2428927) IRS2 [cytosol] (R-HSA-57528) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.589	2
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.577	3
UniProt:P37231 PPARG	2	monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444) PPARG [nucleoplasm] (R-HSA-446172)	0.576	5
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.558	3
UniProt:P37238-1 Pparg	1	Pparg, variant 2 [nucleoplasm] (R-MMU-442491)	0.544	2
UniProt:P04198 MYCN	1	MYCN [nucleoplasm] (R-HSA-452357)	0.544	3
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.544	5
UniProt:Q9UBP5 HEY2	1	HEY2 [nucleoplasm] (R-HSA-1606745)	0.544	3
UniProt:P36956-3 SREBF1	5	SREBF1-3 [nucleoplasm] (R-HSA-1655716) SREBF1-3 [endoplasmic reticulum membrane] (R-HSA-1655761) SREBF1-3 [Golgi membrane] (R-HSA-1655760) SREBF1-3 [Golgi membrane] (R-HSA-1655724) SREBF1-3 [cytosol] (R-HSA-1655721)	0.544	2
UniProt:Q14469 HES1	1	HES1 [nucleoplasm] (R-HSA-210825)	0.544	4
UniProt:P98177 FOXO4	8	FOXO4 [nucleoplasm] (R-HSA-5690183) p-T32,S197,S262-FOXO4 [nucleoplasm] (R-HSA-199314) p-T32,S197,S262-FOXO4 [cytosol] (R-HSA-9614415) SOH-C481-FOXO4 [nucleoplasm] (R-HSA-9617655) CREBBP-S-S-FOXO4 [nucleoplasm] (R-HSA-9617679) EP300-S-S-FOXO4 [nucleoplasm] (R-HSA-9617681) Ac-K-FOXO4 [nucleoplasm] (R-HSA-9617761) PolyUb-FOXO4 [nucleoplasm] (R-HSA-6782501)	0.544	3
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.544	2
UniProt:Q00532 CDKL1			0.527	2
UniProt:P42345 MTOR	2	MTOR [nucleoplasm] (R-HSA-5083674) MTOR [cytosol] (R-HSA-165662)	0.525	2
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.525	3
UniProt:P33076 CIITA	1	CIITA [nucleoplasm] (R-HSA-1031702)	0.524	4
UniProt:Q9NS37 ZHANG			0.524	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.524	3
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.524	3
UniProt:Q04724 TLE1	2	Ub-TLE1 [nucleoplasm] (R-HSA-3322369) TLE1 [nucleoplasm] (R-HSA-212327)	0.508	4
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.508	5
IntAct:EBI-6267604 SIR1			0.499	3
UniProt:Q60644	3	Nr1h2 [cytosol] (R-MMU-9619753) Nr1h2 [nucleoplasm] (R-MMU-4720435) Nr1h2 [nucleoplasm] (R-MMU-375500)	0.499	2
UniProt:Q8N122 RPTOR	3	RPTOR [nucleoplasm] (R-HSA-5083664) RPTOR [cytosol] (R-HSA-3006727) p-S722,S792-RPTOR [cytosol] (R-HSA-3132767)	0.499	3
UniProt:Q9Z0Y9	2	Nr1h3 [nucleoplasm] (R-MMU-4720441) Nr1h3 [nucleoplasm] (R-MMU-3008623)	0.499	2
UniProt:P29590-5 PML			0.463	4
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.462	2
IntAct:EBI-1265559 MYC			0.462	2
IntAct:EBI-5276484 ACTB			0.462	2

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