SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol

Stable Identifier
R-HSA-427555
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The SLC26A1 and 2 genes encode proteins that facilitate sulfate (SO4(2-)) uptake into cells (Alper & Sharma 2013). The mechanism by which these transporters work is unclear but may be enhanced by extracellular halides or acidic pH environments, cotransporting protons electroneutrally. Both can transport SO4(2-) (as well as oxalate and Cl-) across the basolateral membrane of epithelial cells. SLC26A1 encodes the sulfate anion transporter 1 (SAT1) (Regeer et al. 2003) and is most abundantly expressed in the liver and kidney, with lower levels expressed in many other parts of the body. SLC26A2 is ubiquitously expressed and encodes a sulfate transporter (Diastrophic dysplasia protein, DTD, DTDST) (Hastbacka et al. 1994). This transporter provides sulfate for sulfation of glycosaminoglycan chains in proteoglycans needed for cartilage development. Defects in SLC26A2 are implicated in the pathogenesis of several human chondrodysplasias.

Literature References
PubMed ID Title Journal Year
23506885 The SLC26 gene family of anion transporters and channels

Alper, SL, Sharma, AK

Mol. Aspects Med. 2013
12713736 Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1)

Regeer, RR, Lee, A, Markovich, D

DNA Cell Biol 2003
7923357 The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping

de la Chapelle, A, Mahtani, MM, Clines, G, Reeve-Daly, MP, Daly, M, Hamilton, BA, Kusumi, K, Trivedi, B, Weaver, A

Cell 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sulfate transmembrane transporter activity of SLC26A1,2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created