Type II Na+/Pi cotransporters

Stable Identifier
R-HSA-427589
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
Click the image above or here to open this pathway in the Pathway Browser

The SLC34 family of type II Na+/Pi cotransporters consist of three members; NaPi-IIa (SLC34A1), NaPi-IIb (SLC34A2) and NaPi-IIc (SLC34A3) (Murer H et al, 2004). They are expressed mainly in the kidney and small intestine, located at the apical sites of epithelial cells although other areas of the body express them to a lesser extent. NaPi-IIa and b cotransports divalent Pi (HPO4[2-]) with three Na+ ions (electrogenic transport) whereas NaPi-IIc cotransports divalent Pi with two Na+ ions (electroneutral transport).

Literature References
PubMed ID Title Journal Year
12750889 The sodium phosphate cotransporter family SLC34

Murer, H, Forster, I, Biber, J

Pflugers Arch 2004
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database
Authored
Reviewed
Created