Type II Na+/Pi cotransporters

Stable Identifier
R-HSA-427589
Type
Pathway
Species
Homo sapiens
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Summation

The SLC34 family of type II Na+/Pi cotransporters consist of three members; NaPi-IIa (SLC34A1), NaPi-IIb (SLC34A2) and NaPi-IIc (SLC34A3) (Murer H et al, 2004). They are expressed mainly in the kidney and small intestine, located at the apical sites of epithelial cells although other areas of the body express them to a lesser extent. NaPi-IIa and b cotransports divalent Pi (HPO4[2-]) with three Na+ ions (electrogenic transport) whereas NaPi-IIc cotransports divalent Pi with two Na+ ions (electroneutral transport).

Literature References
PubMed ID Title Journal Year
12750889 The sodium phosphate cotransporter family SLC34

Murer, H, Forster, I, Biber, J

Pflugers Arch 2004
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database
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Reviewed