Sodium-coupled phosphate cotransporters

Stable Identifier
R-HSA-427652
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Phosphorus is an essential element that is critical for structural and metabolic roles in all living organisms. Cells obtain phosphorus in the form of negatively-charged inorganic phosphate (Pi). Two SLC families transport phosphate in mammals; SLC34 (Murer H et al, 2004) and SLC20 (Collins JF et al, 2004). Both are secondary-active, Na+-coupled transporter systems which use the inward Na+ gradient (from the Na+-K+-ATPase) to drive phosphate influx into cells (Virkki LV et al, 2007).

Literature References
PubMed ID Title Journal Year
17581921 Phosphate transporters: a tale of two solute carrier families

Virkki, LV, Biber, J, Murer, H, Forster, IC

Am J Physiol Renal Physiol 2007
12750889 The sodium phosphate cotransporter family SLC34

Murer, H, Forster, I, Biber, J

Pflugers Arch 2004
12759754 The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors

Collins, JF, Bai, L, Ghishan, FK

Pflugers Arch 2004
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database
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Reviewed