Sodium-coupled phosphate cotransporters

Stable Identifier
Homo sapiens
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Phosphorus is an essential element that is critical for structural and metabolic roles in all living organisms. Cells obtain phosphorus in the form of negatively-charged inorganic phosphate (Pi). Two SLC families transport phosphate in mammals; SLC34 (Murer H et al, 2004) and SLC20 (Collins JF et al, 2004). Both are secondary-active, Na+-coupled transporter systems which use the inward Na+ gradient (from the Na+-K+-ATPase) to drive phosphate influx into cells (Virkki LV et al, 2007).

Literature References
PubMed ID Title Journal Year
17581921 Phosphate transporters: a tale of two solute carrier families

Virkki, LV, Biber, J, Murer, H, Forster, IC

Am J Physiol Renal Physiol 2007
12750889 The sodium phosphate cotransporter family SLC34

Murer, H, Forster, I, Biber, J

Pflugers Arch 2004
12759754 The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors

Collins, JF, Bai, L, Ghishan, FK

Pflugers Arch 2004
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Orthologous Events
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