Reactome | ATP2A2 [platelet dense tubular network membrane]

ATP2A2 [platelet dense tubular network membrane]

Stable Identifier

R-HSA-427903

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet dense tubular network membrane

Synonyms

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, AT2A2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P16615 ATP2A2

Gene Names

ATP2A2, ATP2B

Chain

chain:1-1042

Reference Genes

BioGPS Gene:488 ATP2A2

COSMIC (genes):ATP2A2 ATP2A2

CTD Gene:488 ATP2A2

dbSNP Gene:488 ATP2A2

ENSEMBL:ENSG00000174437 ATP2A2

HGNC:812 ATP2A2

KEGG Gene (Homo sapiens):488 ATP2A2

Monarch:488 ATP2A2

NCBI Gene:488 ATP2A2

OMIM:108740 ATP2A2

UCSC:P16615 ATP2A2

Reference Transcript

Other Identifiers

0003390528

0003850129

0005900082

11718873_a_at

11718874_s_at

11740332_a_at

11754301_a_at

11754302_a_at

11758558_s_at

16756923

209186_at

212361_s_at

212362_at

239996_3p_x_at

239996_x_at

3431484

3431485

3431487

3431488

3431493

3431497

3431503

3431506

3431507

3431511

3431512

3431513

3431515

3431516

3431517

3431518

3431519

3431520

3431522

3431523

3431526

3431527

3431528

3431529

3431530

3431531

3431532

3431533

3431534

3431535

3431536

3431537

3431538

3431539

3431540

39790_at

39791_at

488

62605

67892

7958644

79971_r_at

83506_at

A0A0C4DH86

A0A0S2Z3L2

A_14_P112250

A_14_P119331

A_23_P53603

A_24_P141786

A_24_P73290

AAA52757

AAA52758

AAA53193

AAA53194

AAH35588

AAO47398

AC006088

AK293877

ALQ33387

ATP2A2

ATP2A2-201

ATP2A2-204

AY186578

BAG57266

BC035588

CCDS9143

CCDS9144

CH471054

EAW97906

ENSG00000174437

ENSP00000311186

ENSP00000440045

ENST00000308664

ENST00000308664.10

ENST00000539276

ENST00000539276.6

EntrezGene:488

EntrezGene:ATP2A2

F8W1Z7

g184100_3p_s_at

GE57875

GE86393

GE86414

GO:0000166

GO:0002026

GO:0003009

GO:0003013

GO:0003674

GO:0005388

GO:0005509

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005789

GO:0005886

GO:0005887

GO:0006810

GO:0006811

GO:0006816

GO:0006874

GO:0006950

GO:0006984

GO:0006996

GO:0007009

GO:0007155

GO:0007165

GO:0007267

GO:0008150

GO:0008544

GO:0008553

GO:0010460

GO:0010882

GO:0012506

GO:0014883

GO:0014898

GO:0016020

GO:0016021

GO:0016192

GO:0016529

GO:0019899

GO:0022857

GO:0030154

GO:0031095

GO:0031234

GO:0031775

GO:0032469

GO:0032470

GO:0032496

GO:0032991

GO:0033017

GO:0033292

GO:0034220

GO:0034599

GO:0034605

GO:0034976

GO:0042592

GO:0043167

GO:0043226

GO:0044325

GO:0044548

GO:0045822

GO:0046872

GO:0048471

GO:0048856

GO:0055085

GO:0055119

GO:0061024

GO:0061831

GO:0070296

GO:0070588

GO:0086036

GO:0086039

GO:0097470

GO:0098909

GO:0120025

GO:1900121

GO:1902600

GO:1903233

GO:1903515

GO:1903779

GO:1990036

HGNC:812

HPA062605

HPA067892

Hs.1526.2.S1_3p_at

Hs.1526.2.S2_3p_a_at

Hs.205454.0.A1_3p_at

Hs.205454.0.A1_3p_x_at

ILMN_1655884

ILMN_1687375

ILMN_1815666

IPR001757

IPR004014

IPR005782

IPR006068

IPR008250

IPR018303

IPR023214

IPR023298

IPR023299

IPR030332

IPR036412

J3QSY6

KU177929

M23114

M23114_at

M23115

M23116

M23278

MIM:101900

MIM:108740

MIM:124200

NM_001681

NM_170665

NP_001672

NP_733765

PF00122

PF00689

PF00690

PF08282

PF13246

PH_hs_0024236

PR00119

PR00120

SM00831

TC12000856.hg

UPI0000001C3A

UPI000002A42A

XM_005253888

XM_011538402

XP_005253945

XP_011536704

XR_002957329

XR_243009

Participant Of

hasMember

ATP2A1-3 [platelet dense tubular network membrane]

Other forms of this molecule

ATP2A2 [endoplasmic reticulum membrane]

Inferred To

sca-1 [platelet dense tubular network membrane] (Caenorhabditis elegans)

atp2a2b [platelet dense tubular network membrane] (Danio rerio)

ATP2A2 [platelet dense tubular network membrane] (Bos taurus)

ATP2A2 [platelet dense tubular network membrane] (Canis familiaris)

ATP2A2 [platelet dense tubular network membrane] (Gallus gallus)

ATP2A2 [platelet dense tubular network membrane] (Plasmodium falciparum)

SERCA [platelet dense tubular network membrane] (Drosophila melanogaster)

atp2a2 [platelet dense tubular network membrane] (Xenopus tropicalis)

Atp2a2 [platelet dense tubular network membrane] (Mus musculus)

Atp2a2 [platelet dense tubular network membrane] (Rattus norvegicus)

Homologues of ATP2A2 [platelet dense tubular network membrane] (Plasmodium falciparum)

Cross References

RefSeq

XP_011536704.1, NP_733765.1, NP_001672.1, XP_005253945.1

Target Pathogen

5b354852be737e166372ebf2

OpenTargets

ENSG00000174437

GeneCards

P16615

HPA

ENSG00000174437-ATP2A2

Ensembl

ENSP00000311186, ENST00000308664, ENSP00000440045, ENST00000539276, ENSG00000174437

PRO

P16615

Orphanet

15324

PDB

6JJU, 5ZTF

HMDB Protein

HMDBP01470

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.527	2
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	2
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:P04578 env	7	Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	2

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