Reactome | CERS2 [endoplasmic reticulum membrane]

CERS2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-428171

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

LASS2, LAG1 homolog, ceramide synthase 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96G23 CERS2

Gene Names

CERS2, LASS2, TMSG1

Chain

chain:1-380

Reference Genes

BioGPS Gene:29956 CERS2

COSMIC (genes):CERS2 CERS2

CTD Gene:29956 CERS2

dbSNP Gene:29956 CERS2

ENSEMBL:ENSG00000143418 CERS2

HGNC:14076 CERS2

KEGG:hsa:29956 CERS2

Monarch:29956 CERS2

NCBI Entrez Gene:29956 CERS2

OMIM:606920 CERS2

UCSC:Q96G23 CERS2

Reference Transcript

Other Identifiers

11720200_s_at

11744724_a_at

16692892

222212_PM_s_at

222212_s_at

2434693

2434717

2434718

2434719

2434720

2434721

2434722

2434723

2434724

2434725

2434726

2434727

2434728

2434729

2434730

2434731

2434732

2434733

2434734

2434735

2434736

2434737

2434738

2434740

2434741

2434742

2434743

2434745

29956

56446_at

7919856

A_23_P63010

GE61615

GO:0003677

GO:0005515

GO:0005634

GO:0005783

GO:0005789

GO:0006629

GO:0006665

GO:0010626

GO:0016020

GO:0016410

GO:0016740

GO:0019216

GO:0030148

GO:0035902

GO:0046513

GO:0048681

GO:0050291

GO:1900148

GO:1905045

HMNXSV003044157

Hs.285976.2.S1_3p_a_at

ILMN_1726108

ILMN_2400500

PH_hs_0014794

TC01003215.hg

Participates

as a member of

Ceramide synthases [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

cers2a [endoplasmic reticulum membrane] (Danio rerio)

crsA [endoplasmic reticulum membrane] (Dictyostelium discoideum)

CERS2 [endoplasmic reticulum membrane] (Bos taurus)

CERS2 [endoplasmic reticulum membrane] (Canis familiaris)

CERS2 [endoplasmic reticulum membrane] (Gallus gallus)

CERS2 [endoplasmic reticulum membrane] (Plasmodium falciparum)

CERS2 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

CERS2 [endoplasmic reticulum membrane] (Sus scrofa)

Homologues of CERS2 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Homologues of CERS2 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Homologues of CERS2 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

lac1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

cers2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

schlank [endoplasmic reticulum membrane] (Drosophila melanogaster)

Cers2 [endoplasmic reticulum membrane] (Mus musculus)

Cers2 [endoplasmic reticulum membrane] (Rattus norvegicus)

hyl-2 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

hyl-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

lag1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_859530.1, XP_011507754.1, NP_071358.1

Guide to Pharmacology - Targets

2475

ENSEMBL

ENSG00000143418, ENSP00000271688, ENST00000368954, ENST00000271688, ENSP00000357950

OpenTargets

ENSG00000143418

GeneCards

CERS2

HPA

ENSG00000143418-CERS2

PRO

Q96G23

Pharos - Targets

Q96G23

GlyGen

Q96G23

HMDB Protein

HMDBP11630

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.73	4
UniProt:O15245 SLC22A1	2	SLC22A1 [plasma membrane] (R-HSA-549126) SLC22A1 [basolateral plasma membrane] (R-HSA-9794526)	0.646	3
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.643	3
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.643	4
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [specific granule membrane] (R-HSA-6799516) C3AR1 [azurophil granule membrane] (R-HSA-6799517)	0.527	2
UniProt:P25103 TACR1	2	TACR1 [plasma membrane] (R-HSA-380103) TACR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869122)	0.527	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470)	0.524	2
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.508	2

Cite Us!