ceramide + H2O => stearate + sphingosine [Golgi]

Stable Identifier
R-HSA-428205
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ACER2 (alkaline ceramidase 2), associated with the membrane of the Golgi apparatus, catalyzes the hydrolysis of ceramide to yield a free fatty acid (annotated here as stearate) and sphingosine. ACER2 mRNA is widely expressed in the body, although only at low levels except in placenta (Xu et al. 2006).

Literature References
PubMed ID Title Journal Year
16940153 Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

Xu, R, Jin, J, Hu, W, Sun, W, Bielawski, J, Szulc, ZM, Taha, T, Obeid, LM, Mao, C

FASEB J 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
N-acylsphingosine amidohydrolase activity of ACER2 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created