ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]

Stable Identifier
R-HSA-428231
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ACER1 (alkaline ceramidase 1), associated with the endoplasmic reticulum membrane, catalyzes the reversible hydrolysis of ceramide to yield a free fatty acid (annotated here as stearate) and sphingosine (Sun et al. 2008).

Literature References
PubMed ID Title Journal Year
17713573 Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes

Sun, W, Xu, R, Hu, W, Jin, J, Crellin, HA, Bielawski, J, Szulc, ZM, Thiers, BH, Obeid, LM, Mao, C

J Invest Dermatol 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
N-acylsphingosine amidohydrolase activity of ACER1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Created