dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O

Stable Identifier
R-HSA-428260
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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DEGS2 (sphingolipid C4-hydroxylase 2 / “degenerative spermatocyte homolog 2”) enzyme associated with the cytosolic face of the endoplasmic reticulum catalyzes the hydroxylation of dihydroceramide to form phytoceramide (Mizutani et al. 2004). Sequence similarity to the bifunctional mouse DEGS2 enzyme suggests that human DEGS2 protein might also catalyze the C4-dehydrogenation of dihydroceramide, but this hypothesis has not been tested experimentally.

Literature References
PubMed ID Title Journal Year
15063729 Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation

Mizutani, Y, Kihara, A, Igarashi, Y

FEBS Lett 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sphingosine hydroxylase activity of DEGS2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
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Created