phytoceramide + H2O => stearate + phytosphingosine

Stable Identifier
R-HSA-428262
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ACER3 (alkaline ceramidase 3) catalyzes the hydrolysis of phytoceramide to yield a free fatty acid (annotated here as stearate) and phytosphingosine. ACER3 mRNA is widely expressed in the body, although most abundant in placenta. Immunofluoresence studies of cultured cells over-expressing GFP-tagged protein suggest its localization to membranes of the endoplasmic reticulum (annotated here) and also the Golgi apparatus (Mao et al. 2001).

Literature References
PubMed ID Title Journal Year
11356846 Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide

Mao, C, Xu, R, Szulc, ZM, Bielawska, A, Galadari, SH, Obeid, LM

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phytoceramidase activity of ACER3 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Created