sphingosine +ATP => sphingosine 1-phosphate + ADP

Stable Identifier
R-HSA-428273
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SPHK1 and 2 (sphingosine kinases 1 and 2) catalyze the reaction of sphingosine and ATP to form sphingosine 1-phosphate and ADP. Both enzymes are found in the cytosol (although they are also present in membrane-associated forms). Both enzymes also catalyze the phosphorylation of sphinganine (dihydrosphingosine) (Liu et al. 2000; Nava et al. 2000; Pitson et al. 2000).

Literature References
PubMed ID Title Journal Year
10751414 Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

Liu, H, Sugiura, M, Nava, VE, Edsall, LC, Kono, K, Poulton, S, Milstien, S, Kohama, T, Spiegel, S

J Biol Chem 2000
10802064 Functional characterization of human sphingosine kinase-1

Nava, VE, Lacana, E, Poulton, S, Liu, H, Sugiura, M, Kono, K, Milstien, S, Kohama, T, Spiegel, S

FEBS Lett 2000
10947957 Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

Pitson, SM, D'Andrea, RJ, Vandeleur, L, Moretti, PA, Xia, P, Gamble, JR, Vadas, MA, Wattenberg, BW

Biochem J 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
D-erythro-sphingosine kinase activity of SPHK [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created