IGF2BP3 binds specific RNAs

Stable Identifier
R-HSA-428287
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IGF2BP3 binds specific RNAs
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Insulin-like Growth Factor mRNA Binding Factor-3 (IGF2BP3, also known as IMP3 and VICKZ3) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA.
Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP3 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive).
Literature References
PubMed ID Title Journal Year
9891060 A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development

Nielsen, J, Wewer, UM, Christiansen, J, Johnsen, AH, Lykke-Andersen, J, Nielsen, FC

Mol Cell Biol 1999
11713986 A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking

Nielsen, J, Christiansen, J, Nielsen, FC

Scand J Clin Lab Invest Suppl 2001
15601260 VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins

Yisraeli, JK

Biol Cell 2005
16541107 RNA-binding IMPs promote cell adhesion and invadopodia formation

Wewer, UM, Hansen, TV, Christiansen, J, Borup, R, Jønson, L, Vikesaa, J, Nielsen, FC

EMBO J 2006
20371350 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP

Landthaler, M, Tuschl, T, Ulrich, A, Ascano M, Jr, Hausser, J, Khorshid, M, Dewell, S, Jungkamp, AC, Wardle, GS, Berninger, P, Munschauer, M, Burger, L, Hafner, M, Zavolan, M, Rothballer, A

Cell 2010
Participants
Input
Output
Participates
as an event of
Authored
May, B  (2009-07-05)
Reviewed
Chao, JA  (2010-05-30)
Singer, RH  (2010-05-30)
Created
May, B  (2009-07-05)
Cite Us!