Reactome | IGF2BP2 [cytosol]

IGF2BP2 [cytosol]

Stable Identifier

R-HSA-428302

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Insulin-like growth factor 2 mRNA-binding protein 2, IF2B2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y6M1 IGF2BP2

Gene Names

IGF2BP2, IMP2, VICKZ2

Chain

chain:1-599

Reference Genes

BioGPS Gene:10644 IGF2BP2

COSMIC (genes):IGF2BP2 IGF2BP2

CTD Gene:10644 IGF2BP2

dbSNP Gene:10644 IGF2BP2

ENSEMBL:ENSG00000073792 IGF2BP2

HGNC:28867 IGF2BP2

Monarch:10644 IGF2BP2

NCBI Gene:10644 IGF2BP2

OMIM:608289 IGF2BP2

UCSC:Q9Y6M1 IGF2BP2

Reference Transcript

Other Identifiers

10644

11741712_a_at

11757763_s_at

16962333

218847_PM_at

218847_at

223963_PM_s_at

223963_s_at

2356661

2356663

2708921

2708923

2708924

2708925

2708926

2708927

2708928

2708929

2708930

2708931

2708932

2708933

2708934

2708936

2708945

2708949

2708957

2708958

2708960

2708961

2708962

2708963

2708967

2708968

2708971

2708973

2708975

2708976

2708980

2709033

2709034

2709039

2709040

2709059

2734718

2734719

3146371

3146372

3412078

3412079

3412080

3412083

3412086

3412087

3412088

3412089

65272_at

65645_at

66842_at

8092552

86029_at

87704_at

A_23_P250156

A_23_P95672

GE58406

GO:0000932

GO:0001817

GO:0003676

GO:0003723

GO:0003730

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0006417

GO:0007399

GO:0009653

GO:0010494

GO:0017148

GO:0043226

GO:0043489

GO:0045182

GO:0048027

GO:0048856

GO:0051028

GO:0060090

GO:0070934

GO:0090079

GO:0097009

GO:0106106

GO:1990247

HMNXSV003003596

ILMN_1702447

PH_hs_0002600

TC03002079.hg

g4191609_3p_a_at

g5729883_3p_at

Participates

as a component of

IGF2BP2:RNA [cytosol] (Homo sapiens)

as an input of

IGF2BP2 binds specific RNAs (Homo sapiens)

Inferred To

Homologues of IGF2BP2 [cytosol] (Plasmodium falciparum)

Homologues of IGF2BP2 [cytosol] (Saccharomyces cerevisiae)

IGF2BP2 [cytosol] (Bos taurus)

IGF2BP2 [cytosol] (Canis familiaris)

IGF2BP2 [cytosol] (Gallus gallus)

IGF2BP2 [cytosol] (Plasmodium falciparum)

IGF2BP2 [cytosol] (Sus scrofa)

Igf2bp2 [cytosol] (Mus musculus)

Igf2bp2 [cytosol] (Rattus norvegicus)

rnc1 [cytosol] (Schizosaccharomyces pombe)

imph-1 [cytosol] (Caenorhabditis elegans)

HEK2 [cytosol] (Saccharomyces cerevisiae)

PBP2 [cytosol] (Saccharomyces cerevisiae)

igf2bp2b [cytosol] (Danio rerio)

Imp [cytosol] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000073792

ENSEMBL

ENST00000421047, ENSP00000320204, ENSP00000371634, ENST00000382199, ENSP00000413787, ENST00000346192

HPA

ENSG00000073792-IGF2BP2

PRO

Q9Y6M1

Pharos - Targets

Q9Y6M1

GlyGen

Q9Y6M1

PDB

2CQH, 6ROL, 7Q99, 7Q98

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.63	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	16
UniProt:Q13148 TADBP			0.556	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.527	2
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	4
UniProt:O95503 CBX6	1	CBX6 [nucleoplasm] (R-HSA-3229071)	0.527	2
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.527	3
UniProt:Q14103-4 HNRNPD	2	HNRNPD-4 [cytosol] (R-HSA-450442) Ub-HNRNPD-4 [cytosol] (R-HSA-451232)	0.527	4
UniProt:P98179 RBM3			0.524	6
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.499	3
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.483	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:O43303 CCP110	2	CCP110 [cytosol] (R-HSA-380261) PolyUb-CCP110 [cytosol] (R-HSA-6783044)	0.483	3

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