Inactivation of RAC1

Stable Identifier
R-HSA-428522
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Vilse and its human homolog ARHGAP39 bind directly to the intracellular domains of the corresponding ROBO receptors and promote the hydrolysis of GTP bound to RAC1 (Lundstrom et al. 2004, Hu et al. 2005).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activator activity of ROBO1:SLIT2:ARHGAP39 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed