Inactivation of CDC42

Stable Identifier
R-HSA-428533
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SRGAP bound to ROBO's cytoplasmic tail increases the intrinsic GTPase activity of CDC42, converting the GTP-bound form of CDC42 into its GDP-bound form, therefore inactivating CDC42. Inactivation of CDC42 leads to a reduction in the activation of the Neuronal Wiskott-Aldrich Syndrome protein (NWASP), thus decreasing the level of the active Arp2/3 complex. Because active Arp2/3 promotes actin polymerization, the reduction of active CDC42 eventually decreases actin polymerization. SLIT regulates SRGAP interaction with ROBO1 and CDC42, increasing SRGAP binding to CDC42 (Wong et al. 2001, Li et al. 2006).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activator activity of SLIT2:ROBO1:SRGAP [plasma membrane]
Physical Entity
Activity
Inferred From