Activation of RAC1

Stable Identifier
R-HSA-428540
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Activation of RAC1
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A low level of RAC1 activity is essential to maintain axon outgrowth. ROBO activation recruits SOS, a dual specificity GEF, to the plasma membrane via Dock homolog NCK (NCK1 or NCK2) to activate RAC1 during midline repulsion.
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Event Information
Go Biological Process
Rac protein signal transduction (0016601)
Authored
Garapati, P V  (2008-09-05)
Reviewed
Jaworski, A  (2017-07-31)
Kidd, T  (2009-08-18)
Created
Garapati, P V  (2009-07-06)
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