Reactome: A Curated Pathway Database

Activation of RAC1

Stable Identifier
R-HSA-428540
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

A low level of RAC1 activity is essential to maintain axon outgrowth. ROBO activation recruits SOS, a dual specificity GEF, to the plasma membrane via Dock homolog NCK (NCK1 or NCK2) to activate RAC1 during midline repulsion.

Participants
Participant Of